SCOPe 2.03: Domain d2f27a_: 2f27 A:

Lineage for d2f27a_ (2f27 A:)

1. Root: SCOPe 2.03

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.68: 6-bladed beta-propeller [50938] (11 superfamilies)
   consists of six 4-stranded beta-sheet motifs; meander

4. Superfamily b.68.1: Sialidases [50939] (3 families)

5. Family b.68.1.1: Sialidases (neuraminidases) [50940] (10 proteins)

6. Protein Sialidase 2 (Neu2) [117274] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117275] (14 PDB entries)
   Uniprot Q9Y3R4

8. Domain d2f27a_: 2f27 A: [164257]
   automated match to d1vcua_
   complexed with dan, epe; mutant

Details for d2f27a_

PDB Entry: 2f27, 2.15 Å

PDB Description: crystal structure of the human sialidase neu2 e111q-q112e double mutant in complex with dana inhibitor

PDB Compounds: (A:) Sialidase 2

SCOPe Domain Sequences for d2f27a_:

Sequence, based on SEQRES records:

>d2f27a_ b.68.1.1 (A:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
maslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdyd
apthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvtqeqqlqtran
vtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpaya
yrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshl
rarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythpth
swqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandye
eivflmftlkqafpaey

Sequence, based on observed residues (ATOM records):

>d2f27a_ b.68.1.1 (A:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
maslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdyd
apthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvtqeqqlqtran
vtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpaya
yrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaeveqrvvtlnarshlrar
vqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprspaqwllythpthswqradl
gaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeeivflmf
tlkqafpaey

Timeline for d2f27a_:

• d2f27a_ first appeared in SCOPe 2.01
  
• d2f27a_ appears in SCOPe 2.02
  
• d2f27a_ appears in SCOPe 2.04
  
• d2f27a_ appears in the current release, SCOPe 2.08