Lineage for d2f25b_ (2f25 B:)

  1. Root: SCOPe 2.08
  2. 2739516Class b: All beta proteins [48724] (180 folds)
  3. 2807606Fold b.68: 6-bladed beta-propeller [50938] (11 superfamilies)
    consists of six 4-stranded beta-sheet motifs; meander
  4. 2807607Superfamily b.68.1: Sialidases [50939] (3 families) (S)
  5. 2807608Family b.68.1.1: Sialidases (neuraminidases) [50940] (10 proteins)
  6. 2807900Protein Sialidase 2 (Neu2) [117274] (1 species)
  7. 2807901Species Human (Homo sapiens) [TaxId:9606] [117275] (14 PDB entries)
    Uniprot Q9Y3R4
  8. 2807908Domain d2f25b_: 2f25 B: [164255]
    automated match to d1vcua_
    complexed with dan, epe; mutant

Details for d2f25b_

PDB Entry: 2f25 (more details), 1.95 Å

PDB Description: crystal structure of the human sialidase neu2 e111q mutant in complex with dana inhibitor
PDB Compounds: (B:) Sialidase 2

SCOPe Domain Sequences for d2f25b_:

Sequence, based on SEQRES records: (download)

>d2f25b_ b.68.1.1 (B:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
maslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdyd
apthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvtqqqqlqtran
vtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpaya
yrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshl
rarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythpth
swqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandye
eivflmftlkqafpaey

Sequence, based on observed residues (ATOM records): (download)

>d2f25b_ b.68.1.1 (B:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
maslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdyd
apthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvtqqqqlqtran
vtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpaya
yrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaeveqrvvtlnarshlrar
vqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprspaqwllythpthswqradl
gaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeeivflmf
tlkqafpaey

SCOPe Domain Coordinates for d2f25b_:

Click to download the PDB-style file with coordinates for d2f25b_.
(The format of our PDB-style files is described here.)

Timeline for d2f25b_: