SCOPe 2.05: Domain d2f25a_: 2f25 A:

Lineage for d2f25a_ (2f25 A:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.68: 6-bladed beta-propeller [50938] (11 superfamilies)
   consists of six 4-stranded beta-sheet motifs; meander

4. Superfamily b.68.1: Sialidases [50939] (3 families)

5. Family b.68.1.1: Sialidases (neuraminidases) [50940] (10 proteins)

6. Protein Sialidase 2 (Neu2) [117274] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117275] (14 PDB entries)
   Uniprot Q9Y3R4

8. Domain d2f25a_: 2f25 A: [164254]
   automated match to d1vcua_
   complexed with dan, epe; mutant

Details for d2f25a_

PDB Entry: 2f25, 1.95 Å

PDB Description: crystal structure of the human sialidase neu2 e111q mutant in complex with dana inhibitor

PDB Compounds: (A:) Sialidase 2

SCOPe Domain Sequences for d2f25a_:

Sequence, based on SEQRES records:

>d2f25a_ b.68.1.1 (A:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
maslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdyd
apthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvtqqqqlqtran
vtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpaya
yrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshl
rarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprsgpgspaqwllythpth
swqradlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandye
eivflmftlkqafpaey

Sequence, based on observed residues (ATOM records):

>d2f25a_ b.68.1.1 (A:) Sialidase 2 (Neu2) {Human (Homo sapiens) [TaxId: 9606]}
maslpvlqkesvfqsgahayripallylpgqqsllafaeqraskkdehaelivlrrgdyd
apthqvqwqaqevvaqarldghrsmnpcplydaqtgtlflffiaipgqvtqqqqlqtran
vtrlcqvtstdhgrtwssprdltdaaigpayrewstfavgpghclqlndrarslvvpaya
yrklhpiqrpipsafcflshdhgrtwarghfvaqdtlecqvaevetgeqrvvtlnarshl
rarvqaqstndgldfqesqlvkklvepppqgcqgsvisfpsprspaqwllythpthswqr
adlgaylnprppapeawsepvllakgscaysdlqsmgtgpdgsplfgclyeandyeeivf
lmftlkqafpaey

Timeline for d2f25a_:

• d2f25a_ first appeared in SCOPe 2.01
  
• d2f25a_ appears in SCOPe 2.04
  
• d2f25a_ appears in SCOPe 2.06
  
• d2f25a_ appears in the current release, SCOPe 2.08