Lineage for d2c7vc_ (2c7v C:)

  1. Root: SCOPe 2.06
  2. 2089713Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2102557Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2102558Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2102904Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2104213Protein automated matches [190085] (51 species)
    not a true protein
  7. 2104737Species Trypanosoma brucei [TaxId:5702] [187520] (4 PDB entries)
  8. 2104752Domain d2c7vc_: 2c7v C: [163292]
    automated match to d1mxfa_
    complexed with act, mtx, nap, ni

Details for d2c7vc_

PDB Entry: 2c7v (more details), 2.2 Å

PDB Description: structure of trypanosoma brucei pteridine reductase (ptr1) in ternary complex with cofactor and the antifolate methotrexate
PDB Compounds: (C:) pteridine reductase

SCOPe Domain Sequences for d2c7vc_:

Sequence, based on SEQRES records: (download)

>d2c7vc_ c.2.1.2 (C:) automated matches {Trypanosoma brucei [TaxId: 5702]}
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqgdhednsngktvetqva
eligtnaiapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkhal
vgltqsaalelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadav
iflvsgsaqyitgsiikvdgglslvha

Sequence, based on observed residues (ATOM records): (download)

>d2c7vc_ c.2.1.2 (C:) automated matches {Trypanosoma brucei [TaxId: 5702]}
eapaavvtgaakrigraiavklhqtgyrvvihyhnsaeaavsladelnkersntavvcqa
dltnsnvlpasceeiinscfrafgrcdvlvnnasafyptplvqggktvetqvaeligtna
iapflltmsfaqrqkgtnpnctssnlsivnlcdamvdqpcmafslynmgkhalvgltqsa
alelapygirvngvapgvsllpvamgeeekdkwrrkvplgrreasaeqiadaviflvsgs
aqyitgsiikvdgglslvha

SCOPe Domain Coordinates for d2c7vc_:

Click to download the PDB-style file with coordinates for d2c7vc_.
(The format of our PDB-style files is described here.)

Timeline for d2c7vc_: