SCOPe 2.05: Domain d2b0ta_: 2b0t A:

Lineage for d2b0ta_ (2b0t A:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
   consists of two intertwined (sub)domains related by pseudo dyad; duplication
   3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest

4. Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (6 families)
   the constituent families form similar dimers

5. Family c.77.1.2: Monomeric isocitrate dehydrogenase [82526] (2 proteins)
   the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion
   automatically mapped to Pfam PF03971

6. Protein automated matches [190493] (2 species)
   not a true protein

7. Species Corynebacterium glutamicum [TaxId:1718] [187435] (1 PDB entry)

8. Domain d2b0ta_: 2b0t A: [162961]
   automated match to d1itwa_
   complexed with mg

Details for d2b0ta_

PDB Entry: 2b0t, 1.75 Å

PDB Description: Structure of Monomeric NADP Isocitrate dehydrogenase

PDB Compounds: (A:) NADP Isocitrate dehydrogenase

SCOPe Domain Sequences for d2b0ta_:

Sequence; same for both SEQRES and ATOM records:

>d2b0ta_ c.77.1.2 (A:) automated matches {Corynebacterium glutamicum [TaxId: 1718]}
akiiwtrtdeapllatyslkpvveafaatagievetrdislagrilaqfperltedqkvg
nalaelgelaktpeaniiklpnisasvpqlkaaikelqdqgydipelpdnattdeekdil
arynavkgsavnpvlregnsdrrapiavknfvkkfphrmgewsadsktnvatmdandfrh
neksiildaadevqikhiaadgtetilkdslkllegevldgtvlsakaldaflleqvara
kaegilfsahlkatmmkvsdpiifghvvrayfadvfaqygeqllaaglngenglaailsg
lesldngeeikaafekgledgpdlamvnsargitnlhvpsdvivdasmpamirtsghmwn
kddqeqdtlaiipdssyagvyqtviedcrkngafdpttmgtvpnvglmaqkaeeygshdk
tfrieadgvvqvvssngdvliehdveandiwracqvkdapiqdwvklavtrsrlsgmpav
fwldperahdrnlaslvekyladhdtegldiqilspveatqlsidrirrgedtisvtgnv
lrdyntdlfpilelgtsakmlsvvplmaggglfetgaggsapkhvqqvqeenhlrwdslg
eflalaesfrhelnnngntkagvladaldkatekllneekspsrkvgeidnrgshfwltk
fwadelaaqtedadlaatfapvaealntgaadidaallavqggatdlggyyspneekltn
imrpvaqfneivdal

Timeline for d2b0ta_:

• d2b0ta_ first appeared in SCOPe 2.01
  
• d2b0ta_ appears in SCOPe 2.04
  
• d2b0ta_ appears in SCOPe 2.06
  
• d2b0ta_ appears in the current release, SCOPe 2.08