SCOPe 2.06: Domain d2aztb_: 2azt B:

Lineage for d2aztb_ (2azt B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.66: S-adenosyl-L-methionine-dependent methyltransferases [53334] (1 superfamily)
   core: 3 layers, a/b/a; mixed beta-sheet of 7 strands, order 3214576; strand 7 is antiparallel to the rest

4. Superfamily c.66.1: S-adenosyl-L-methionine-dependent methyltransferases [53335] (60 families)

5. Family c.66.1.5: Glycine N-methyltransferase [53348] (1 protein)

6. Protein Glycine N-methyltransferase [53349] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [110664] (2 PDB entries)
   Uniprot Q14749

8. Domain d2aztb_: 2azt B: [162953]
   automated match to d1r74a_
   complexed with bme, cit, cl; mutant

Details for d2aztb_

PDB Entry: 2azt, 2.7 Å

PDB Description: crystal structure of h176n mutant of human glycine n-methyltransferase

PDB Compounds: (B:) glycine n-methyltransferase

SCOPe Domain Sequences for d2aztb_:

Sequence, based on SEQRES records:

>d2aztb_ c.66.1.5 (B:) Glycine N-methyltransferase {Human (Homo sapiens) [TaxId: 9606]}
yrtrslgvaaeglpdqyadgeaarvwqlyigdtrsrtaeykawllgllrqhgcqrvldva
cgtgvdsimlveegfsvtsvdasdkmlkyalkerwnrrhepafdkwvieeanwmtldkdv
pqsaeggfdaviclgnsfahlpdckgdqsehrlalkniasmvraggllvidnrnydhils
tgcappgkniyyksdltkdvttsvlivnnkahmvtldytvqvpgagqdgspglskfrlsy
yphclasftellqaafggkcqhsvlgdfkpykpgqtyipcyfihvlkrt

Sequence, based on observed residues (ATOM records):

>d2aztb_ c.66.1.5 (B:) Glycine N-methyltransferase {Human (Homo sapiens) [TaxId: 9606]}
yrtrslgvaaeglpdqyadgeaarvwqlyigdtrsrtaeykawllgllrqhgcqrvldva
cgtgvdsimlveegfsvtsvdasdkmlkyalkerwnrrhepafdkwvieeanwmtldkdv
pqeggfdaviclgnsfahlpdckgdqsehrlalkniasmvraggllvidnrnydhilstg
cappgkniyyksdltkdvttsvlivnnkahmvtldytvqglskfrlsyyphclasftell
qaafggkcqhsvlgdfkpykpgqtyipcyfihvlkrt

Timeline for d2aztb_:

• d2aztb_ first appeared in SCOPe 2.01
  
• d2aztb_ appears in SCOPe 2.05
  
• d2aztb_ appears in SCOPe 2.07
  
• d2aztb_ appears in the current release, SCOPe 2.08