SCOPe 2.06: Domain d2ax8a_: 2ax8 A:

Lineage for d2ax8a_ (2ax8 A:)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein Androgen receptor [63621] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63623] (62 PDB entries)
   Uniprot P10275 671-919

8. Domain d2ax8a_: 2ax8 A: [162943]
   automated match to d1e3ga_
   complexed with fhm; mutant

Details for d2ax8a_

PDB Entry: 2ax8, 1.7 Å

PDB Description: crystal structure of the androgen receptor ligand binding domain w741l mutant in complex with s-1

PDB Compounds: (A:) Androgen receptor

SCOPe Domain Sequences for d2ax8a_:

Sequence, based on SEQRES records:

>d2ax8a_ a.123.1.1 (A:) Androgen receptor {Human (Homo sapiens) [TaxId: 9606]}
iflnvleaiepgvvcaghdnnqpdsfaallsslnelgerqlvhvvkwakalpgfrnlhvd
dqmaviqyslmglmvfamgwrsftnvnsrmlyfapdlvfneyrmhksrmysqcvrmrhls
qefgwlqitpqeflcmkalllfsiipvdglknqkffdelrmnyikeldriiackrknpts
csrrfyqltklldsvqpiarelhqftfdllikshmvsvdfpemmaeiisvqvpkilsgkv
kpiyfh

Sequence, based on observed residues (ATOM records):

>d2ax8a_ a.123.1.1 (A:) Androgen receptor {Human (Homo sapiens) [TaxId: 9606]}
iflnvleaiepgvvcaghdnnqpdsfaallsslnelgerqlvhvvkwakalpgfrnlhvd
dqmaviqyslmglmvfamgwrsftnvnsrmlyfapdlvfneyrmhksrmysqcvrmrhls
qefgwlqitpqeflcmkalllfsiipvdglknqkffdelrmnyikeldriiacsrrfyql
tklldsvqpiarelhqftfdllikshmvsvdfpemmaeiisvqvpkilsgkvkpiyfh

Timeline for d2ax8a_:

• d2ax8a_ first appeared in SCOPe 2.01
  
• d2ax8a_ appears in SCOPe 2.05
  
• d2ax8a_ appears in SCOPe 2.07
  
• d2ax8a_ appears in the current release, SCOPe 2.08