SCOPe 2.01: Domain d1y9ra_: 1y9r A:

Lineage for d1y9ra_ (1y9r A:)

1. Root: SCOPe 2.01

2. Class a: All alpha proteins [46456] (284 folds)

3. Fold a.123: Nuclear receptor ligand-binding domain [48507] (1 superfamily)
   multihelical; 3 layers or orthogonally packed helices

4. Superfamily a.123.1: Nuclear receptor ligand-binding domain [48508] (2 families)

5. Family a.123.1.1: Nuclear receptor ligand-binding domain [48509] (34 proteins)

6. Protein automated matches [190059] (10 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187214] (97 PDB entries)

8. Domain d1y9ra_: 1y9r A: [162170]
   automated match to d1m2za_
   complexed with 1ca; mutant

Details for d1y9ra_

PDB Entry: 1y9r, 1.96 Å

PDB Description: crystal structure of the human mineralocorticoid receptor ligand- binding domain bound to deoxycorticosterone and harboring the s810l mutation responsible for a severe form of hypertension

PDB Compounds: (A:) Mineralocorticoid receptor

SCOPe Domain Sequences for d1y9ra_:

Sequence, based on SEQRES records:

>d1y9ra_ a.123.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
spvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpgfknlple
dqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqis
lqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtkapnnsgq
swqrfyqltklldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgna
kplyfhr

Sequence, based on observed residues (ATOM records):

>d1y9ra_ a.123.1.1 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
spvmvleniepeivyagydsskpdtaenllstlnrlagkqmiqvvkwakvlpgfknlple
dqitliqyswmcllsfalswrsykhtnsqflyfapdlvfneekmhqsamyelcqgmhqis
lqfvrlqltfeeytimkvllllstipkdglksqaafeemrtnyikelrkmvtswqrfyql
tklldsmhdlvsdllefcfytfreshalkvefpamlveiisdqlpkvesgnakplyfhr

Timeline for d1y9ra_:

• d1y9ra_ is new in SCOPe 2.01-stable
  
• d1y9ra_ appears in SCOPe 2.02
  
• d1y9ra_ appears in the current release, SCOPe 2.08