SCOPe 2.07: Protein: Aspartoacylase AspA

Lineage for Protein: Aspartoacylase AspA

Root: SCOPe 2.07
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
Superfamily c.56.5: Zn-dependent exopeptidases [53187] (10 families)
core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest

Family c.56.5.7: AstE/AspA-like [142526] (3 protein domains)
Pfam PF04952; Succinylglutamate desuccinylase / Aspartoacylase family; contains extra C-terminal domain, new variant of the Barrel-sandwich hybrid fold (51229)

Protein Aspartoacylase AspA [159649] (2 species)

Species:

Human (Homo sapiens) [TaxId:9606] [159651] (5 PDB entries)
Uniprot P45381 9-310
1. Domains for 2i3c:
  1. Domain d2i3ca1: 2i3c A:9-310 [147498]
    complexed with po4, zn
  2. Domain d2i3cb_: 2i3c B: [161460]
    automated match to d2i3ca1
    complexed with po4, zn
2. Domains for 2o4h:
  1. Domain d2o4ha_: 2o4h A: [166534]
    automated match to d2i3ca1
    complexed with as9, zn
  2. Domain d2o4hb_: 2o4h B: [166535]
    automated match to d2i3ca1
    complexed with as9, zn
3. Domains for 2o53:
  1. Domain d2o53a_: 2o53 A: [166552]
    automated match to d2i3ca1
    complexed with po4, zn
  2. Domain d2o53b_: 2o53 B: [166553]
    automated match to d2i3ca1
    complexed with po4, zn
4. Domains for 2q51:
  1. Domain d2q51a_: 2q51 A: [167416]
    automated match to d2i3ca1
    complexed with po4, zn
  2. Domain d2q51b_: 2q51 B: [167417]
    automated match to d2i3ca1
    complexed with po4, zn
5. Domains for 4tnu:
  1. Domain d4tnua_: 4tnu A: [258530]
    automated match to d2gu2a1
    complexed with as9, zn; mutant
  2. Domain d4tnub_: 4tnu B: [260033]
    automated match to d2gu2a1
    complexed with as9, zn; mutant
Norway rat (Rattus norvegicus) [TaxId:10116] [159650] (1 PDB entry)
Uniprot Q6AZ03 4-310
- Domains for 2gu2:
  1. Domain d2gu2a1: 2gu2 A:4-310 [147177]
    complexed with so4, zn
  2. Domain d2gu2b_: 2gu2 B: [161444]
    automated match to d2gu2a1
    complexed with so4, zn

More info for Protein Aspartoacylase AspA from c.56.5.7: AstE/AspA-like

Timeline for Protein Aspartoacylase AspA from c.56.5.7: AstE/AspA-like:

Protein Aspartoacylase AspA from c.56.5.7: AstE/AspA-like first appeared in SCOP 1.75
Protein Aspartoacylase AspA from c.56.5.7: AstE/AspA-like appears in SCOPe 2.06