Lineage for Protein: Aspartoacylase AspA

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2125386Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
    core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops
  4. 2126724Superfamily c.56.5: Zn-dependent exopeptidases [53187] (10 families) (S)
    core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest
  5. 2127107Family c.56.5.7: AstE/AspA-like [142526] (3 protein domains)
    Pfam PF04952; Succinylglutamate desuccinylase / Aspartoacylase family; contains extra C-terminal domain, new variant of the Barrel-sandwich hybrid fold (51229)
  6. 2127108Protein Aspartoacylase AspA [159649] (2 species)

Species:

  1. 2127109Human (Homo sapiens) [TaxId:9606] [159651] (5 PDB entries)
    Uniprot P45381 9-310
    1. Domains for 2i3c:
      1. 2127112Domain d2i3ca1: 2i3c A:9-310 [147498]
        complexed with po4, zn
      2. 2127113Domain d2i3cb_: 2i3c B: [161460]
        automated match to d2i3ca1
        complexed with po4, zn
    2. Domains for 2o4h:
      1. 2127110Domain d2o4ha_: 2o4h A: [166534]
        automated match to d2i3ca1
        complexed with as9, zn
      2. 2127111Domain d2o4hb_: 2o4h B: [166535]
        automated match to d2i3ca1
        complexed with as9, zn
    3. Domains for 2o53:
      1. 2127116Domain d2o53a_: 2o53 A: [166552]
        automated match to d2i3ca1
        complexed with po4, zn
      2. 2127117Domain d2o53b_: 2o53 B: [166553]
        automated match to d2i3ca1
        complexed with po4, zn
    4. Domains for 2q51:
      1. 2127114Domain d2q51a_: 2q51 A: [167416]
        automated match to d2i3ca1
        complexed with po4, zn
      2. 2127115Domain d2q51b_: 2q51 B: [167417]
        automated match to d2i3ca1
        complexed with po4, zn
    5. Domains for 4tnu:
      1. 2127118Domain d4tnua_: 4tnu A: [258530]
        automated match to d2gu2a1
        complexed with as9, zn; mutant
      2. 2127119Domain d4tnub_: 4tnu B: [260033]
        automated match to d2gu2a1
        complexed with as9, zn; mutant
  2. 2127120Norway rat (Rattus norvegicus) [TaxId:10116] [159650] (1 PDB entry)
    Uniprot Q6AZ03 4-310

More info for Protein Aspartoacylase AspA from c.56.5.7: AstE/AspA-like

Timeline for Protein Aspartoacylase AspA from c.56.5.7: AstE/AspA-like: