SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Species: Human (Homo sapiens) [TaxId: 9606]

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2096453Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
    core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
  4. 2096454Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families) (S)
  5. 2096508Family c.3.1.2: FAD-linked reductases, N-terminal domain [51913] (18 protein domains)
    C-terminal domain is alpha+beta is common for the family
  6. 2096593Protein Lysine-specific histone demethylase 1, LSD1 [159432] (1 species)
  7. 2096594Species Human (Homo sapiens) [TaxId:9606] [159433] (27 PDB entries)
    Uniprot O60341 274-654,764-836

PDB entries in Species: Human (Homo sapiens) [TaxId: 9606]:

  1. Domain(s) for 2dw4:
  2. Domain(s) for 2ejr:
  3. Domain(s) for 2h94:
  4. Domain(s) for 2iw5:
  5. Domain(s) for 2uxn:
  6. Domain(s) for 2uxx:
  7. Domain(s) for 2xaf:
  8. Domain(s) for 2xag:
  9. Domain(s) for 2xah:
  10. Domain(s) for 2xaj:
  11. Domain(s) for 2xaq:
  12. Domain(s) for 2xas:
  13. Domain(s) for 2z3y:
  14. Domain(s) for 2z5u:
  15. Domain(s) for 3zms:
  16. Domain(s) for 3zmt:
  17. Domain(s) for 3zmu:
  18. Domain(s) for 3zmv:
  19. Domain(s) for 3zmz:
  20. Domain(s) for 3zn0:
  21. Domain(s) for 3zn1:
  22. Domain(s) for 4uv8:
  23. Domain(s) for 4uv9:
  24. Domain(s) for 4uva:
  25. Domain(s) for 4uvb:
  26. Domain(s) for 4uvc:
  27. Domain(s) for 4uxn:

More info for Species Human (Homo sapiens) [TaxId:9606] from c.3.1.2 Lysine-specific histone demethylase 1, LSD1

Timeline for Species Human (Homo sapiens) [TaxId:9606] from c.3.1.2 Lysine-specific histone demethylase 1, LSD1: