SCOPe 2.08: Protein: Lysine-specific histone demethylase 1, LSD1

Lineage for Protein: Lysine-specific histone demethylase 1, LSD1

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander
Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (9 families)
Family c.3.1.2: FAD-linked reductases, N-terminal domain [51913] (18 proteins)
C-terminal domain is alpha+beta is common for the family
Protein Lysine-specific histone demethylase 1, LSD1 [159432] (1 species)

Species:

Human (Homo sapiens) [TaxId:9606] [159433] (27 PDB entries)
Uniprot O60341 274-654,764-836

Domain for 2dw4:
- Domain d2dw4a2: 2dw4 A:274-654,A:764-831 [146595]
  Other proteins in same PDB: d2dw4a1, d2dw4a3
  automatically matched to 2IW5 A:274-654,A:764-836
  complexed with fad
Domain for 2ejr:
- Domain d2ejra2: 2ejr A:274-654,A:764-831 [146878]
  Other proteins in same PDB: d2ejra1, d2ejra3
  automatically matched to 2IW5 A:274-654,A:764-836
  complexed with f2n
Domain for 2h94:
- Domain d2h94a2: 2h94 A:274-654,A:764-835 [147246]
  Other proteins in same PDB: d2h94a1, d2h94a3
  automatically matched to 2IW5 A:274-654,A:764-836
  complexed with fad, hg

Domain for 2iw5:

Domain d2iw5a2: 2iw5 A:274-654,A:764-836 [145540]
Other proteins in same PDB: d2iw5a1, d2iw5a3, d2iw5b1, d2iw5b2
includes the CoREST-binding subdomain (420-520), a long alpha-helical hairpin
complexed with cl, fad, gol, nh4

Domain for 2uxn:
- Domain d2uxna2: 2uxn A:274-654,A:764-836 [145761]
  Other proteins in same PDB: d2uxna1, d2uxna3, d2uxnb1
  automatically matched to 2IW5 A:274-654,A:764-836
  complexed with cl, fda, gol
Domain for 2uxx:
- Domain d2uxxa2: 2uxx A:274-654,A:764-835 [152311]
  Other proteins in same PDB: d2uxxa1, d2uxxa3, d2uxxb1, d2uxxb2
  automated match to d2iw5a2
  complexed with cl, faj, gol
Domain for 2xaf:
- Domain d2xafa2: 2xaf A:274-654,A:764-836 [264563]
  Other proteins in same PDB: d2xafa1, d2xafa3, d2xafb1, d2xafb2
  complexed with fad, tcf
Domain for 2xag:
- Domain d2xaga2: 2xag A:274-654,A:764-836 [264568]
  Other proteins in same PDB: d2xaga1, d2xaga3, d2xagb1, d2xagb2
  complexed with fad, tcf
Domain for 2xah:
- Domain d2xaha2: 2xah A:274-654,A:764-836 [264573]
  Other proteins in same PDB: d2xaha1, d2xaha3, d2xahb1, d2xahb2
  complexed with 3pl, fad
Domain for 2xaj:
- Domain d2xaja2: 2xaj A:274-654,A:764-836 [264578]
  Other proteins in same PDB: d2xaja1, d2xaja3, d2xajb1, d2xajb2
  complexed with fad, tca
Domain for 2xaq:
- Domain d2xaqa2: 2xaq A:274-654,A:764-836 [264583]
  Other proteins in same PDB: d2xaqa1, d2xaqa3, d2xaqb1, d2xaqb2
  complexed with fad, m84
Domain for 2xas:
- Domain d2xasa2: 2xas A:274-654,A:764-836 [264588]
  Other proteins in same PDB: d2xasa1, d2xasa3, d2xasb1, d2xasb2
  complexed with fad, m80
Domain for 2z3y:
- Domain d2z3ya2: 2z3y A:274-654,A:764-831 [154025]
  Other proteins in same PDB: d2z3ya1, d2z3ya3
  automatically matched to 2IW5 A:274-654,A:764-836
  complexed with f2n
Domain for 2z5u:
- Domain d2z5ua2: 2z5u A:274-654,A:764-831 [154168]
  Other proteins in same PDB: d2z5ua1, d2z5ua3
  automatically matched to 2IW5 A:274-654,A:764-836
  complexed with faj
Domain for 3zms:
- Domain d3zmsa2: 3zms A:274-654,A:764-836 [265820]
  Other proteins in same PDB: d3zmsa1, d3zmsa3, d3zmsb1, d3zmsb2
  complexed with fad
Domain for 3zmt:
- Domain d3zmta2: 3zmt A:274-654,A:764-836 [265825]
  Other proteins in same PDB: d3zmta1, d3zmta3, d3zmtb1, d3zmtb2
  complexed with fad
Domain for 3zmu:
- Domain d3zmua2: 3zmu A:274-654,A:764-836 [265830]
  Other proteins in same PDB: d3zmua1, d3zmua3, d3zmub1, d3zmub2
  complexed with fad
Domain for 3zmv:
- Domain d3zmva2: 3zmv A:274-654,A:764-836 [265835]
  Other proteins in same PDB: d3zmva1, d3zmva3, d3zmvb1, d3zmvb2
  complexed with fad
Domain for 3zmz:
- Domain d3zmza2: 3zmz A:274-654,A:764-836 [265840]
  Other proteins in same PDB: d3zmza1, d3zmza3, d3zmzb1, d3zmzb2
  complexed with fad
Domain for 3zn0:
- Domain d3zn0a2: 3zn0 A:274-654,A:764-836 [265845]
  Other proteins in same PDB: d3zn0a1, d3zn0a3, d3zn0b1, d3zn0b2
  complexed with fad
Domain for 3zn1:
- Domain d3zn1a2: 3zn1 A:274-654,A:764-836 [265850]
  Other proteins in same PDB: d3zn1a1, d3zn1a3, d3zn1b1, d3zn1b2
  complexed with fad
Domain for 4uv8:
- Domain d4uv8a2: 4uv8 A:274-654,A:764-836 [267480]
  Other proteins in same PDB: d4uv8a1, d4uv8a3, d4uv8b1, d4uv8b2
  complexed with d69
Domain for 4uv9:
- Domain d4uv9a2: 4uv9 A:274-654,A:764-836 [267485]
  Other proteins in same PDB: d4uv9a1, d4uv9a3, d4uv9b1, d4uv9b2
  complexed with d70
Domain for 4uva:
- Domain d4uvaa2: 4uva A:274-654,A:764-836 [267490]
  Other proteins in same PDB: d4uvaa1, d4uvaa3, d4uvab1, d4uvab2
  complexed with d73
Domain for 4uvb:
- Domain d4uvba2: 4uvb A:274-654,A:764-836 [267495]
  Other proteins in same PDB: d4uvba1, d4uvba3, d4uvbb1, d4uvbb2
  complexed with d51
Domain for 4uvc:
- Domain d4uvca2: 4uvc A:274-654,A:764-836 [267500]
  Other proteins in same PDB: d4uvca1, d4uvca3, d4uvcb1, d4uvcb2
  complexed with d52
Domain for 4uxn:
- Domain d4uxna2: 4uxn A:274-654,A:764-836 [269431]
  Other proteins in same PDB: d4uxna1, d4uxna3, d4uxnb1, d4uxnb2
  automated match to d2xafa2
  complexed with fad, m8a

More info for Protein Lysine-specific histone demethylase 1, LSD1 from c.3.1.2: FAD-linked reductases, N-terminal domain

Timeline for Protein Lysine-specific histone demethylase 1, LSD1 from c.3.1.2: FAD-linked reductases, N-terminal domain:

Protein Lysine-specific histone demethylase 1, LSD1 from c.3.1.2: FAD-linked reductases, N-terminal domain first appeared in SCOP 1.75
Protein Lysine-specific histone demethylase 1, LSD1 from c.3.1.2: FAD-linked reductases, N-terminal domain appears in SCOPe 2.07