SCOPe 2.07: Family a.60.1.3: Variant SAM domain

Lineage for Family a.60.1.3: Variant SAM domain

1. Root: SCOPe 2.07

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.60: SAM domain-like [47768] (16 superfamilies)
   4-5 helices; bundle of two orthogonally packed alpha-hairpins; involved in the interactions with DNA and proteins

4. Superfamily a.60.1: SAM/Pointed domain [47769] (4 families)

5. Family a.60.1.3: Variant SAM domain [158526] (2 proteins)
   shares a sequence motif with Pfam PF07647, but has a distinct packing of helices

Proteins:

1. Deleted in liver cancer 1 protein, DLC-1 [158529] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [158530] (2 PDB entries)
     Uniprot Q96QB1 1-76! Uniprot Q96QB1 1-78

2. Deleted in Liver Cancer 2, DLC2 [158527] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [158528] (2 PDB entries)
     Uniprot Q9Y3M8 50-120

More info for Family a.60.1.3: Variant SAM domain

Timeline for Family a.60.1.3: Variant SAM domain:

• Family a.60.1.3: Variant SAM domain first appeared in SCOP 1.75
  
• Family a.60.1.3: Variant SAM domain appears in SCOPe 2.06
  
• Family a.60.1.3: Variant SAM domain appears in the current release, SCOPe 2.08