SCOPe 2.05: Domain d3e93a_: 3e93 A:

Lineage for d3e93a_ (3e93 A:)

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (12 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (553 PDB entries)

8. Domain d3e93a_: 3e93 A: [158066]
   automated match to d1a9ua_
   complexed with 19b, gol

Details for d3e93a_

PDB Entry: 3e93, 2 Å

PDB Description: crystal structure of p38 kinase in complex with a biaryl amide inhibitor

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d3e93a_:

Sequence, based on SEQRES records:

>d3e93a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyv
atrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpg
aellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqal
ahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppl

Sequence, based on observed residues (ATOM records):

>d3e93a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfgltddemtgyvatr
wyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgael
lkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalaha
yfaqyhdpddepvadpydqsfesrdllidewksltydevisfvpppl

Timeline for d3e93a_:

• d3e93a_ first appeared in SCOP 1.75, called d3e93a1
  
• d3e93a_ appears in SCOPe 2.04
  
• d3e93a_ appears in SCOPe 2.06
  
• d3e93a_ appears in the current release, SCOPe 2.08