SCOPe 2.08: Domain d3dokb_: 3dok B:

Lineage for d3dokb_ (3dok B:)

1. Root: SCOPe 2.08

2. Class e: Multi-domain proteins (alpha and beta) [56572] (74 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (9 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (3 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (4 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (206 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d3dokb_: 3dok B: [157819]
   Other proteins in same PDB: d3doka2
   automated match to d1c1cb_
   complexed with gwj, po4; mutant

Details for d3dokb_

PDB Entry: 3dok, 2.9 Å

PDB Description: crystal structure of k103n mutant hiv-1 reverse transcriptase in complex with gw678248.

PDB Compounds: (B:) p51 RT

SCOPe Domain Sequences for d3dokb_:

Sequence, based on SEQRES records:

>d3dokb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikkk
dstkwrklvdfrelnkrtqdfwevqlgiphpaglkknksvtvldvgdayfsvpldedfrk
ytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymdd
lyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpivl
pekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelelaen
reilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvk
qlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklw
yqlek

Sequence, based on observed residues (ATOM records):

>d3dokb_ e.8.1.2 (B:) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
tvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaikst
kwrklvdfrelnkrtqdfwgiphpaglkknksvtvldvgdayfsvpldedfrkytaftip
sinnetpgiryqynvlpqgwkgspaifqssmtkilepfrkqnpdiviyqymddlyvgsdl
eigqhrtkieelrqhllrwglttelhpdkwtvqpivlpekdswtvndiqklvgklnwasq
iypgikvrqlckllrgtkalteviplteeaelelaenreilkepvhgvyydpskdliaei
qkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlteavqkittesiviwgktpkf
klpiqketwetwwteywqatwipewefvntpplvklwyqlek

Timeline for d3dokb_:

• d3dokb_ first appeared in SCOP 1.75, called d3dokb1
  
• d3dokb_ appears in SCOPe 2.07