SCOPe 2.03: Domain d3dhpa2: 3dhp A:1-403

Lineage for d3dhpa2 (3dhp A:1-403)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.1: TIM beta/alpha-barrel [51350] (33 superfamilies)
   contains parallel beta-sheet barrel, closed; n=8, S=8; strand order 12345678
   the first seven superfamilies have similar phosphate-binding sites

4. Superfamily c.1.8: (Trans)glycosidases [51445] (15 families)

5. Family c.1.8.1: Amylase, catalytic domain [51446] (26 proteins)
   members of the family may contain various insert subdomains
   in alpha-amylases and closer relatives this domain is usually followed by a common all-beta domain

6. Protein Animal alpha-amylase [51458] (3 species)
   contains Ca2+-binding subdomain, residues 100-170

7. Species Human (Homo sapiens) [TaxId:9606] [51460] (53 PDB entries)
   Uniprot P04746 16-511 ! SQ 04746

8. Domain d3dhpa2: 3dhp A:1-403 [157726]
   Other proteins in same PDB: d3dhpa1
   automatically matched to d1c8qa2
   complexed with ca, cl, glc, hmc

Details for d3dhpa2

PDB Entry: 3dhp, 1.5 Å

PDB Description: probing the role of aromatic residues at the secondary saccharide binding sites of human salivary alpha-amylase in substrate hydrolysis and bacterial binding

PDB Compounds: (A:) Alpha-amylase 1

SCOPe Domain Sequences for d3dhpa2:

Sequence; same for both SEQRES and ATOM records:

>d3dhpa2 c.1.8.1 (A:1-403) Animal alpha-amylase {Human (Homo sapiens) [TaxId: 9606]}
eyssntqqgrtsivhlfewrwvdialecerylapkgfggvqvsppnenvaihnpfrpwwe
ryqpvsyklctrsgnedefrnmvtrcnnvgvriyvdavinhmcgnavsagtsstcgsyfn
pgsrdfpavpysgadfndgkcktgsgdienyndatqvrdcrlsglldlalgkdyvrskia
eymnhlidigvagfridaskhmapgdikaildklhnlnsnwfpegskpfiyqevidlgge
pikssdyfgngrvtefkygaklgtvirkwngekmsalknwgegagfmpsdralvfvdnhd
nqrghgaggasiltfadarlykmavgfmlahpygftrvmssyrwpryfengkdvndwvgp
pndngvtkevtinpdttcgndwvcehrarqirnmvnfrnvvdg

Timeline for d3dhpa2:

• d3dhpa2 first appeared in SCOP 1.75
  
• d3dhpa2 appears in SCOPe 2.02
  
• d3dhpa2 appears in SCOPe 2.04
  
• d3dhpa2 appears in the current release, SCOPe 2.08