SCOPe 2.05: Domain d3dekc_: 3dek C:

Lineage for d3dekc_ (3dek C:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein automated matches [190398] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187267] (13 PDB entries)

8. Domain d3dekc_: 3dek C: [157590]
   automated match to d1nmqa_
   complexed with rxd

Details for d3dekc_

PDB Entry: 3dek, 2.4 Å

PDB Description: crystal structures of caspase-3 with bound isoquinoline-1,3,4-trione derivative inhibitors

PDB Compounds: (C:) Caspase-3

SCOPe Domain Sequences for d3dekc_:

Sequence, based on SEQRES records:

>d3dekc_ c.17.1.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnkndltr
eeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrcrsltg
kpklfiiqacrgteldcgietdsgvdddmachkipvdadflyaystapgyyswrnskdgs
wfiqslcamlkqyadklefmhiltrvnrkvatefesfsfdatfhakkqipcivsmltkel
yfyh

Sequence, based on observed residues (ATOM records):

>d3dekc_ c.17.1.1 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnkndltr
eeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrcrsltg
kpklfiiqacrgteldcgietdhkipvdadflyaystapgyyswrnskdgswfiqslcam
lkqyadklefmhiltrvnrkvatefesfsfdatfhakkqipcivsmltkelyfyh

Timeline for d3dekc_:

• d3dekc_ first appeared in SCOP 1.75, called d3dekc1
  
• d3dekc_ appears in SCOPe 2.04
  
• d3dekc_ appears in SCOPe 2.06
  
• d3dekc_ appears in the current release, SCOPe 2.08