SCOPe 2.05: Domain d3dehd_: 3deh D:

Lineage for d3dehd_ (3deh D:)

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.17: Caspase-like [52128] (1 superfamily)
   3 layers, a/b/a; core: mixed beta-sheet of 6 strands, order 213456, strand 6 is antiparallel to the rest

4. Superfamily c.17.1: Caspase-like [52129] (3 families)
   mature protein may be composed of two chains folded in a single domain

5. Family c.17.1.1: Caspase catalytic domain [52130] (8 proteins)

6. Protein automated matches [190398] (2 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187267] (13 PDB entries)

8. Domain d3dehd_: 3deh D: [157579]
   automated match to d1nmqa_
   complexed with rxa

Details for d3dehd_

PDB Entry: 3deh, 2.5 Å

PDB Description: crystal structures of caspase-3 with bound isoquinoline-1,3,4-trione derivative inhibitors

PDB Compounds: (D:) Caspase-3

SCOPe Domain Sequences for d3dehd_:

Sequence, based on SEQRES records:

>d3dehd_ c.17.1.1 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnkndltr
eeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrcrsltg
kpklfiiqacrgteldcgietdsgvdddmachkipvdadflyaystapgyyswrnskdgs
wfiqslcamlkqyadklefmhiltrvnrkvatefesfsfdatfhakkqipcivsmltkel
yfy

Sequence, based on observed residues (ATOM records):

>d3dehd_ c.17.1.1 (D:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
dnsykmdypemglciiinnknfhkstgmtsrsgtdvdaanlretfrnlkyevrnkndltr
eeivelmrdvskedhskrssfvcvllshgeegiifgtngpvdlkkitnffrgdrcrsltg
kpklfiiqacrgteldcgihkipvdadflyaystapgyyswrnskswfiqslcamlkqya
dklefmhiltrvnrkvatefesfsfdatfhakkqipcivsmltkelyfy

Timeline for d3dehd_:

• d3dehd_ first appeared in SCOP 1.75, called d3dehd1
  
• d3dehd_ appears in SCOPe 2.04
  
• d3dehd_ appears in SCOPe 2.06
  
• d3dehd_ appears in the current release, SCOPe 2.08