Lineage for d3dbhe_ (3dbh E:)

  1. Root: SCOPe 2.06
  2. 2089713Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2168353Fold c.111: Activating enzymes of the ubiquitin-like proteins [69571] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 32145678; strands 6 and 8 are antiparallel to the rest
  4. 2168354Superfamily c.111.1: Activating enzymes of the ubiquitin-like proteins [69572] (3 families) (S)
    transfer adenylyl group to the C-terminal carboxyl group of the ubiquitin and MoaD/ThiS-related proteins
    the ATP nucleotide-binding site is similar to that of the NAD-binding Rossmann-folds
  5. 2168361Family c.111.1.2: Ubiquitin activating enzymes (UBA) [89763] (3 proteins)
    the common fold is elaborated with additional (sub)domains
  6. 2168362Protein Amyloid beta precursor protein-binding protein 1, APPBP1 [89766] (1 species)
    a subunit of the heterodimeric E1 enzyme for NEDD8; contains a large insertion (residues 170-487) that can be divided into 3 units similar to the UBA3 insertion
  7. 2168363Species Human (Homo sapiens) [TaxId:9606] [89767] (10 PDB entries)
    Uniprot Q13564
  8. 2168372Domain d3dbhe_: 3dbh E: [157470]
    Other proteins in same PDB: d3dbhb1, d3dbhb2, d3dbhd1, d3dbhd2, d3dbhf1, d3dbhf2, d3dbhh1, d3dbhh2, d3dbhi2, d3dbhi3, d3dbhj_, d3dbhk_, d3dbhl_
    automated match to d1tt5a_
    complexed with zn

Details for d3dbhe_

PDB Entry: 3dbh (more details), 2.85 Å

PDB Description: structural dissection of a gating mechanism preventing misactivation of ubiquitin by nedd8's e1 (appbp1-uba3arg190ala-nedd8ala72arg)
PDB Compounds: (E:) NEDD8-activating enzyme E1 regulatory subunit

SCOPe Domain Sequences for d3dbhe_:

Sequence, based on SEQRES records: (download)

>d3dbhe_ c.111.1.2 (E:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens) [TaxId: 9606]}
kllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqv
sgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftv
vvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrl
dkpfpelrehfqsydldhmekkdhshtpwiviiakylaqwysetngripktykekedfrd
lirqgilkpedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwilara
lkefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigq
apesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylmlr
avdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaaep
htiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

Sequence, based on observed residues (ATOM records): (download)

>d3dbhe_ c.111.1.2 (E:) Amyloid beta precursor protein-binding protein 1, APPBP1 {Human (Homo sapiens) [TaxId: 9606]}
kllkeqkydrqlrlwgdhgqealesahvclinatatgteilknlvlpgigsftiidgnqv
sgedagnnfflqrssigknraeaameflqelnsdvsgsfveespenlldndpsffcrftv
vvatqlpestslrladvlwnsqipllicrtyglvgymriiikehpvieshpdnaledlrl
dkpfpelrehfqsydldhekkdhshtpwiviiakylaqwysetngripktykekedfrdl
irqgilkpedeenfeeaiknvntalnttqipssiedifnddrcinitkqtpsfwilaral
kefvakegqgnlpvrgtipdmiadsgkyiklqnvyrekakkdaaavgnhvakllqsigqa
pesisekelkllcsnsaflrvvrcrslaeeygldtinkdeiissmdnpdneivlylmlra
vdrfhkqqgrypgvsnyqveedigklkscltgflqeyglsvmvkddyvhefcrygaaeph
tiaaflggaaaqevikiitkqfvifnntyiysgmsqtsatfql

SCOPe Domain Coordinates for d3dbhe_:

Click to download the PDB-style file with coordinates for d3dbhe_.
(The format of our PDB-style files is described here.)

Timeline for d3dbhe_: