SCOPe 2.08: Domain d3d85d2: 3d85 D:88-211

Lineage for d3d85d2 (3d85 D:88-211)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.2: Fibronectin type III [49265] (2 families)

5. Family b.1.2.1: Fibronectin type III [49266] (45 proteins)
   Pfam PF00041

6. Protein The p40 domain of interleukin-12 (IL-12 beta chain), domains 2 and 3 [63672] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [63673] (5 PDB entries)

8. Domain d3d85d2: 3d85 D:88-211 [157440]
   Other proteins in same PDB: d3d85a1, d3d85a2, d3d85b_, d3d85d1
   automatically matched to d1f42a2
   complexed with imd, mpd

Details for d3d85d2

PDB Entry: 3d85, 1.9 Å

PDB Description: crystal structure of il-23 in complex with neutralizing fab

PDB Compounds: (D:) Interleukin-12 subunit p40

SCOPe Domain Sequences for d3d85d2:

Sequence, based on SEQRES records:

>d3d85d2 b.1.2.1 (D:88-211) The p40 domain of interleukin-12 (IL-12 beta chain), domains 2 and 3 {Human (Homo sapiens) [TaxId: 9606]}
giwstdilkdqkepknktflrceaknysgrftcwwlttistdltfsvkssrgssdpqgvt
cgaatlsaervrgdnkeyeysvecqedsacpaaeeslpievmvdavhklkyeqytssffi
rdii

Sequence, based on observed residues (ATOM records):

>d3d85d2 b.1.2.1 (D:88-211) The p40 domain of interleukin-12 (IL-12 beta chain), domains 2 and 3 {Human (Homo sapiens) [TaxId: 9606]}
giwstdilkdqknktflrceaknysgrftcwwlttistdltfsvkssrgssdpqgvtcga
atlsaervrnkeyeysvecqedsacpaaeeslpievmvdavhklkyeqytssffirdii

Timeline for d3d85d2:

• d3d85d2 first appeared in SCOP 1.75
  
• d3d85d2 appears in SCOPe 2.07