SCOPe 2.06: Domain d3d5qa2: 3d5q A:24-289

Lineage for d3d5qa2 (3d5q A:24-289)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
   Uniprot P28845

8. Domain d3d5qa2: 3d5q A:24-289 [157399]
   Other proteins in same PDB: d3d5qa3, d3d5qb3, d3d5qc3, d3d5qd3
   automated match to d1xu9a_
   complexed with nap, t30

Details for d3d5qa2

PDB Entry: 3d5q, 2.55 Å

PDB Description: crystal structure of 11b-hsd1 in complex with triazole inhibitor

PDB Compounds: (A:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d3d5qa2:

Sequence, based on SEQRES records:

>d3d5qa2 c.2.1.2 (A:24-289) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
neefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelga
asahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevn
flsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysv
srvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslw
ttllirnpsrkileflystsynmdrf

Sequence, based on observed residues (ATOM records):

>d3d5qa2 c.2.1.2 (A:24-289) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
neefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelga
asahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevn
flsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysv
srvnvsitlcvlglidtetamkavmqaapkeecaleiikggalrqeevyydsslwttlli
rnpsrkileflystsynmdrf

Timeline for d3d5qa2:

• d3d5qa2 first appeared in SCOP 1.75, called d3d5qa1
  
• d3d5qa2 was called d3d5qa_ in SCOPe 2.05
  
• d3d5qa2 appears in SCOPe 2.07
  
• d3d5qa2 appears in the current release, SCOPe 2.08