SCOP 1.75: Domain d3d4na1: 3d4n A:25-282

Lineage for d3d4na1 (3d4n A:25-282)

1. Root: SCOP 1.75

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)

7. Species Human (Homo sapiens) [TaxId:9606] [117424] (11 PDB entries)
   Uniprot P28845

8. Domain d3d4na1: 3d4n A:25-282 [157296]
   automatically matched to d1xu9b_
   complexed with d4n, nap; mutant

Details for d3d4na1

PDB Entry: 3d4n, 2.5 Å

PDB Description: crystal structure of human 11-beta-hydroxysteroid dehydrogenase (hsd1) in complex with sulfonamide inhibitor

PDB Compounds: (A:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOP Domain Sequences for d3d4na1:

Sequence, based on SEQRES records:

>d3d4na1 c.2.1.2 (A:25-282) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
eefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaa
sahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnf
lsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvs
rvnvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwt
tllirnpsrkileflyst

Sequence, based on observed residues (ATOM records):

>d3d4na1 c.2.1.2 (A:25-282) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}
eefrpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaa
sahyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnf
lsyvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvs
rvnvsitlcvlglidtetamkavsivhmqaapkeecaleiikggalrqeevyydsslwtt
llirnpsrkileflyst

Timeline for d3d4na1:

• d3d4na1 is new in SCOP 1.75
  
• d3d4na1 is called d3d4na_ in SCOPe 2.01
  
• d3d4na1 appears in the current release, SCOPe 2.08, called d3d4na2