SCOPe 2.02: Domain d3ctha_: 3cth A:

Lineage for d3ctha_ (3cth A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (22 PDB entries)

8. Domain d3ctha_: 3cth A: [156983]
   automated match to d1r0pa_
   complexed with 319

Details for d3ctha_

PDB Entry: 3cth, 2.3 Å

PDB Description: crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d3ctha_:

Sequence, based on SEQRES records:

>d3ctha_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
hidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavks
lnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirn
ethnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfglardmyd
kefdsvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfd
itvyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvh
vnatyvnvk

Sequence, based on observed residues (ATOM records):

>d3ctha_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
hidlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavks
lnritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirn
ethnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfgnktgakl
pvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqp
eycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvnatyvnvk

Timeline for d3ctha_:

• d3ctha_ first appeared in SCOP 1.75, called d3ctha1
  
• d3ctha_ appears in SCOPe 2.01
  
• d3ctha_ appears in SCOPe 2.03
  
• d3ctha_ appears in the current release, SCOPe 2.08