SCOP 1.75: Domain d3ctha1: 3cth A:1054-1360

Lineage for d3ctha1 (3cth A:1054-1360)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (63 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (6 PDB entries)

8. Domain d3ctha1: 3cth A:1054-1360 [156983]
   automatically matched to d1r0pa_
   complexed with 319; mutant

Details for d3ctha1

PDB Entry: 3cth, 2.3 Å

PDB Description: crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a aminopyridine based inhibitor

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOP Domain Sequences for d3ctha1:

Sequence, based on SEQRES records:

>d3ctha1 d.144.1.7 (A:1054-1360) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
dlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavksln
ritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnet
hnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfglardmydke
fdsvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfdit
vyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvn
atyvnvk

Sequence, based on observed residues (ATOM records):

>d3ctha1 d.144.1.7 (A:1054-1360) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
dlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavksln
ritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnet
hnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfgnktgaklpv
kwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpey
cpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvnatyvnvk

Timeline for d3ctha1:

• d3ctha1 is new in SCOP 1.75
  
• d3ctha1 is called d3ctha_ in SCOPe 2.01
  
• d3ctha1 appears in the current release, SCOPe 2.08, called d3ctha_