SCOPe 2.07: Domain d3ckrc_: 3ckr C:

Lineage for d3ckrc_ (3ckr C:)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein automated matches [190156] (5 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187237] (38 PDB entries)

8. Domain d3ckrc_: 3ckr C: [156745]
   automated match to d1fkna_
   complexed with 009

Details for d3ckrc_

PDB Entry: 3ckr, 2.7 Å

PDB Description: crystal structure of bace-1 in complex with inhibitor

PDB Compounds: (C:) Beta-secretase 1

SCOPe Domain Sequences for d3ckrc_:

Sequence, based on SEQRES records:

>d3ckrc_ b.50.1.2 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmi
iggidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlr
lpkkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqs
fritilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfa
vsachvhdefrtaavegpfvtldmedcgyni

Sequence, based on observed residues (ATOM records):

>d3ckrc_ b.50.1.2 (C:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
kgsfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrq
lsstyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnw
egilglayaeiarpddslepffdslvkqthvpnlfslqlcgsvggsmiiggidhslytgs
lwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavks
ikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylr
pveatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaa
vegpfvtldmedcgyni

Timeline for d3ckrc_:

• d3ckrc_ first appeared in SCOP 1.75, called d3ckrc1
  
• d3ckrc_ appears in SCOPe 2.06
  
• d3ckrc_ appears in the current release, SCOPe 2.08