SCOP 1.75: Domain d3ckrc1: 3ckr C:-2-385

Lineage for d3ckrc1 (3ckr C:-2-385)

1. Root: SCOP 1.75

2. Class b: All beta proteins [48724] (174 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (3 families)

5. Family b.50.1.2: Pepsin-like [50646] (10 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (51 PDB entries)
   Uniprot P56817 58-446
   Uniprot P56817 60-447
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d3ckrc1: 3ckr C:-2-385 [156745]
   automatically matched to d1fkna_
   complexed with 009; mutant

Details for d3ckrc1

PDB Entry: 3ckr, 2.7 Å

PDB Description: crystal structure of bace-1 in complex with inhibitor

PDB Compounds: (C:) Beta-secretase 1

SCOP Domain Sequences for d3ckrc1:

Sequence, based on SEQRES records:

>d3ckrc1 b.50.1.2 (C:-2-385) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgyn

Sequence, based on observed residues (ATOM records):

>d3ckrc1 b.50.1.2 (C:-2-385) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgsvggsmiiggidhslytgslwy
tpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksika
asstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpve
atsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaaveg
pfvtldmedcgyn

Timeline for d3ckrc1:

• d3ckrc1 is new in SCOP 1.75
  
• d3ckrc1 is called d3ckrc_ in SCOPe 2.01
  
• d3ckrc1 appears in the current release, SCOPe 2.08, called d3ckrc_