SCOPe 2.05: Domain d3ckpb_: 3ckp B:

Lineage for d3ckpb_ (3ckp B:)

1. Root: SCOPe 2.05

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein automated matches [190156] (4 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187237] (38 PDB entries)

8. Domain d3ckpb_: 3ckp B: [156741]
   automated match to d1fkna_
   complexed with 012, cl

Details for d3ckpb_

PDB Entry: 3ckp, 2.3 Å

PDB Description: crystal structure of bace-1 in complex with inhibitor

PDB Compounds: (B:) Beta-secretase 1

SCOPe Domain Sequences for d3ckpb_:

Sequence, based on SEQRES records:

>d3ckpb_ b.50.1.2 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgyni

Sequence, based on observed residues (ATOM records):

>d3ckpb_ b.50.1.2 (B:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgsvggsmiiggidhslytgslwy
tpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksika
asstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpve
dvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaav
egpfvtldmedcgyni

Timeline for d3ckpb_:

• d3ckpb_ first appeared in SCOP 1.75, called d3ckpb1
  
• d3ckpb_ appears in SCOPe 2.04
  
• d3ckpb_ appears in SCOPe 2.06
  
• d3ckpb_ appears in the current release, SCOPe 2.08