SCOPe 2.02: Domain d3ce3a_: 3ce3 A:

Lineage for d3ce3a_ (3ce3 A:)

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (64 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Hepatocyte growth factor receptor, c-MET [103300] (1 species)
   PTK group; HGFR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103301] (22 PDB entries)

8. Domain d3ce3a_: 3ce3 A: [156520]
   automated match to d1r0pa_
   complexed with 1fn

Details for d3ce3a_

PDB Entry: 3ce3, 2.4 Å

PDB Description: crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-met in complex with a pyrrolopyridinepyridone based inhibitor

PDB Compounds: (A:) Hepatocyte growth factor receptor

SCOPe Domain Sequences for d3ce3a_:

Sequence, based on SEQRES records:

>d3ce3a_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
dlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavksln
ritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnet
hnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfglardmydke
fdsvhnktgaklpvkwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfdit
vyllqgrrllqpeycpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvn
atyvnvk

Sequence, based on observed residues (ATOM records):

>d3ce3a_ d.144.1.7 (A:) Hepatocyte growth factor receptor, c-MET {Human (Homo sapiens) [TaxId: 9606]}
dlsalnpelvqavqhvvigpsslivhfnevigrghfgcvyhgtlldndgkkihcavksln
ritdigevsqfltegiimkdfshpnvlsllgiclrsegsplvvlpymkhgdlrnfirnet
hnptvkdligfglqvakgmkflaskkfvhrdlaarncmldekftvkvadfgnktgaklpv
kwmaleslqtqkfttksdvwsfgvllwelmtrgappypdvntfditvyllqgrrllqpey
cpdplyevmlkcwhpkaemrpsfselvsrisaifstfigehyvhvnatyvnvk

Timeline for d3ce3a_:

• d3ce3a_ first appeared in SCOP 1.75, called d3ce3a1
  
• d3ce3a_ appears in SCOPe 2.01
  
• d3ce3a_ appears in SCOPe 2.03
  
• d3ce3a_ appears in the current release, SCOPe 2.08