SCOPe 2.08: Domain d3c9wa2: 3c9w A:7-354

Lineage for d3c9wa2 (3c9w A:7-354)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein MAP kinase Erk2 [56134] (2 species)
   CMGC group; ERK/MAPK subfamily; serine/threonine kinase

7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [56136] (58 PDB entries)

8. Domain d3c9wa2: 3c9w A:7-354 [156148]
   Other proteins in same PDB: d3c9wa3, d3c9wb3
   automated match to d2erka_
   complexed with hmy

Details for d3c9wa2

PDB Entry: 3c9w, 2.5 Å

PDB Description: crystal structure of erk-2 with hypothemycin covalently bound

PDB Compounds: (A:) Mitogen-activated protein kinase 1

SCOPe Domain Sequences for d3c9wa2:

Sequence, based on SEQRES records:

>d3c9wa2 d.144.1.7 (A:7-354) MAP kinase Erk2 {Norway rat (Rattus norvegicus) [TaxId: 10116]}
agpemvrgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrt
lreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicy
flyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdhtgflteyv
atrwyrapeimlnskgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgsps
qedlnciinlkarnyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqal
ahpyleqyydpsdepiaeapfkfdmelddlpkeklkelifeetarfqp

Sequence, based on observed residues (ATOM records):

>d3c9wa2 d.144.1.7 (A:7-354) MAP kinase Erk2 {Norway rat (Rattus norvegicus) [TaxId: 10116]}
agpemvrgqvfdvgprytnlsyigegaygmvcsaydnlnkvrvaikkispfehqtycqrt
lreikillrfrheniigindiiraptieqmkdvyivqdlmetdlykllktqhlsndhicy
flyqilrglkyihsanvlhrdlkpsnlllnttcdlkicdfglarvadptrwyrapeimln
skgytksidiwsvgcilaemlsnrpifpgkhyldqlnhilgilgspsqedlnciinlkar
nyllslphknkvpwnrlfpnadskaldlldkmltfnphkrieveqalahpyleqyydpsd
epiaeapfkfdmelddlpkeklkelifeetarfqp

Timeline for d3c9wa2:

• d3c9wa2 first appeared in SCOP 1.75, called d3c9wa1
  
• d3c9wa2 appears in SCOPe 2.07