SCOPe 2.06: Domain d3c10a_: 3c10 A:

Lineage for d3c10a_ (3c10 A:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.42: Arginase/deacetylase [52767] (1 superfamily)
   3 layers: a/b/a, parallel beta-sheet of 8 strands, order 21387456

4. Superfamily c.42.1: Arginase/deacetylase [52768] (3 families)

5. Family c.42.1.2: Histone deacetylase, HDAC [52773] (4 proteins)
   automatically mapped to Pfam PF00850

6. Protein Histone deacetylase 7, HDAC7 [159582] (1 species)
   HDAC7a

7. Species Human (Homo sapiens) [TaxId:9606] [159583] (8 PDB entries)
   Uniprot Q8WUI4 515-900

8. Domain d3c10a_: 3c10 A: [155847]
   automated match to d3c0ya1
   complexed with k, tsn, zn

Details for d3c10a_

PDB Entry: 3c10, 2 Å

PDB Description: Crystal structure of catalytic domain of human histone deacetylase HDAC7 in complex with Trichostatin A (TSA)

PDB Compounds: (A:) Histone deacetylase 7a

SCOPe Domain Sequences for d3c10a_:

Sequence, based on SEQRES records:

>d3c10a_ c.42.1.2 (A:) Histone deacetylase 7, HDAC7 {Human (Homo sapiens) [TaxId: 9606]}
tlpfttgliydsvmlkhqcscgdnsrhpehagriqsiwsrlqerglrsqceclrgrkasl
eelqsvhserhvllygtnplsrlkldngklagllaqrmfvmlpcggvgvdtdtiwnelhs
snaarwaagsvtdlafkvasrelkngfavvrppghhadhstamgfcffnsvaiacrqlqq
qskaskilivdwdvhhgngtqqtfyqdpsvlyislhrhddgnffpgsgavdevgagsgeg
fnvnvawaggldppmgdpeylaafrivvmpiarefspdlvlvsagfdaaeghpaplggyh
vsakcfgymtqqlmnlaggavvlalegghdltaicdaseacvaallgnrvdplseegwkq
kpnlnairsleavirvhskywgcmqr

Sequence, based on observed residues (ATOM records):

>d3c10a_ c.42.1.2 (A:) Histone deacetylase 7, HDAC7 {Human (Homo sapiens) [TaxId: 9606]}
tlpfttgliydsvmlkhqcscgdnsrhpehagriqsiwsrlqerglrsqceclrgrkasl
eelqsvhserhvllygtnplsrlkldngklagllaqvmlpcggvgvdtdtiwnelhssna
arwaagsvtdlafkvasrelkngfavvrppghhadhstamgfcffnsvaiacrqlqqqsk
askilivdwdvhhgngtqqtfyqdpsvlyislhrhddgnffpgsgavdevgagsgegfnv
nvawaggldppmgdpeylaafrivvmpiarefspdlvlvsagfdaaeghpaplggyhvsa
kcfgymtqqlmnlaggavvlalegghdltaicdaseacvaallgnrvdplseegwkqkpn
lnairsleavirvhskywgcmqr

Timeline for d3c10a_:

• d3c10a_ first appeared in SCOP 1.75, called d3c10a1
  
• d3c10a_ appears in SCOPe 2.05
  
• d3c10a_ appears in SCOPe 2.07
  
• d3c10a_ appears in the current release, SCOPe 2.08