SCOP 1.75: Domain d3bz3a1: 3bz3 A:414-686

Lineage for d3bz3a1 (3bz3 A:414-686)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (63 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Focal adhesion kinase 1 (fak) [103292] (1 species)
   PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103293] (4 PDB entries)

8. Domain d3bz3a1: 3bz3 A:414-686 [155738]
   automatically matched to d1mp8a_
   complexed with yam

Details for d3bz3a1

PDB Entry: 3bz3, 2.2 Å

PDB Description: crystal structure analysis of focal adhesion kinase with a methanesulfonamide diaminopyrimidine inhibitor

PDB Compounds: (A:) Focal adhesion kinase 1

SCOP Domain Sequences for d3bz3a1:

Sequence, based on SEQRES records:

>d3bz3a1 d.144.1.7 (A:414-686) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
dyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqeal
tmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlsta
layleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpikwmapes
infrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlys
lmtkcwaydpsrrprftelkaqlstileeekaq

Sequence, based on observed residues (ATOM records):

>d3bz3a1 d.144.1.7 (A:414-686) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
dyeiqrerielgrcigegqfgdvhqgiymsplavaiktcknctsdsvrekflqealtmrq
fdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstalayl
eskrfvhrdiaarnvlvssndcvklgdfglsrylpikwmapesinfrrftsasdvwmfgv
cmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprft
elkaqlstileeekaq

Timeline for d3bz3a1:

• d3bz3a1 is new in SCOP 1.75
  
• d3bz3a1 is called d3bz3a_ in SCOPe 2.01
  
• d3bz3a1 appears in the current release, SCOPe 2.08, called d3bz3a_