SCOPe 2.08: Domain d3bz3a_: 3bz3 A:

Lineage for d3bz3a_ (3bz3 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Focal adhesion kinase 1 (fak) [103292] (2 species)
   PTK group; FAK subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [103293] (23 PDB entries)

8. Domain d3bz3a_: 3bz3 A: [155738]
   automated match to d1mp8a_
   complexed with yam

Details for d3bz3a_

PDB Entry: 3bz3, 2.2 Å

PDB Description: crystal structure analysis of focal adhesion kinase with a methanesulfonamide diaminopyrimidine inhibitor

PDB Compounds: (A:) Focal adhesion kinase 1

SCOPe Domain Sequences for d3bz3a_:

Sequence, based on SEQRES records:

>d3bz3a_ d.144.1.7 (A:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
dyeiqrerielgrcigegqfgdvhqgiymspenpalavaiktcknctsdsvrekflqeal
tmrqfdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlsta
layleskrfvhrdiaarnvlvssndcvklgdfglsrymedstyykaskgklpikwmapes
infrrftsasdvwmfgvcmweilmhgvkpfqgvknndvigriengerlpmppncpptlys
lmtkcwaydpsrrprftelkaqlstileeekaqqee

Sequence, based on observed residues (ATOM records):

>d3bz3a_ d.144.1.7 (A:) Focal adhesion kinase 1 (fak) {Human (Homo sapiens) [TaxId: 9606]}
dyeiqrerielgrcigegqfgdvhqgiymsplavaiktcknctsdsvrekflqealtmrq
fdhphivkligvitenpvwiimelctlgelrsflqvrkysldlaslilyayqlstalayl
eskrfvhrdiaarnvlvssndcvklgdfglsrylpikwmapesinfrrftsasdvwmfgv
cmweilmhgvkpfqgvknndvigriengerlpmppncpptlyslmtkcwaydpsrrprft
elkaqlstileeekaqqee

Timeline for d3bz3a_:

• d3bz3a_ first appeared in SCOP 1.75, called d3bz3a1
  
• d3bz3a_ appears in SCOPe 2.07