SCOPe 2.07: Domain d3bu5a_: 3bu5 A:

Lineage for d3bu5a_ (3bu5 A:)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Insulin receptor [56162] (1 species)
   PTK group; InsR subfamily; membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56163] (18 PDB entries)

8. Domain d3bu5a_: 3bu5 A: [155591]
   automated match to d1p14a_
   complexed with atp, mg

Details for d3bu5a_

PDB Entry: 3bu5, 2.1 Å

PDB Description: crystal structure of the insulin receptor kinase in complex with irs2 krlb peptide and atp

PDB Compounds: (A:) insulin receptor subunit beta

SCOPe Domain Sequences for d3bu5a_:

Sequence, based on SEQRES records:

>d3bu5a_ d.144.1.7 (A:) Insulin receptor {Human (Homo sapiens) [TaxId: 9606]}
dewevsrekitllrelgqgsfgmvyegnardiikgeaetrvavktvnesaslreriefln
easvmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslrpeaennpgrppptl
qemiqmaaeiadgmaylnakkfvhrdlaarncmvahdftvkigdfgmtrdiyetdyyrkg
gkgllpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqglsneqvlkfvmdgg
yldqpdncpervtdlmrmcwqfnpnmrptfleivnllkddlhpsfpevsffhseenk

Sequence, based on observed residues (ATOM records):

>d3bu5a_ d.144.1.7 (A:) Insulin receptor {Human (Homo sapiens) [TaxId: 9606]}
dewevsrekitllrelgqgmvyegnardiikgeaetrvavktvnesaslrerieflneas
vmkgftchhvvrllgvvskgqptlvvmelmahgdlksylrslrpeaennpgrppptlqem
iqmaaeiadgmaylnakkfvhrdlaarncmvahdftvkigdfgmtrdiyetdyyrkggkg
llpvrwmapeslkdgvfttssdmwsfgvvlweitslaeqpyqglsneqvlkfvmdggyld
qpdncpervtdlmrmcwqfnpnmrptfleivnllkddlhpsfpevsffhseenk

Timeline for d3bu5a_:

• d3bu5a_ first appeared in SCOP 1.75, called d3bu5a1
  
• d3bu5a_ appears in SCOPe 2.06
  
• d3bu5a_ appears in the current release, SCOPe 2.08