SCOP 1.75: Domain d3b2wa1: 3b2w A:238-498

Lineage for d3b2wa1 (3b2w A:238-498)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (63 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein Lymphocyte kinase (lck) [56153] (1 species)
   PTK group; Src subfamily; non-membrane spanning protein tyrosine kinase

7. Species Human (Homo sapiens) [TaxId:9606] [56154] (17 PDB entries)

8. Domain d3b2wa1: 3b2w A:238-498 [154804]
   automatically matched to d1qpca_
   complexed with 9nh

Details for d3b2wa1

PDB Entry: 3b2w, 2.3 Å

PDB Description: Crystal structure of pyrimidine amide 11 bound to Lck

PDB Compounds: (A:) Proto-oncogene tyrosine-protein kinase LCK

SCOP Domain Sequences for d3b2wa1:

Sequence, based on SEQRES records:

>d3b2wa1 d.144.1.7 (A:238-498) Lymphocyte kinase (lck) {Human (Homo sapiens) [TaxId: 9606]}
wevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanlmkqlqh
qrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafiee
rnyihrdlraanilvsdtlsckiadfglarliedneytaregakfpikwtapeainygtf
tiksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrlcw
kerpedrptfdylrsvledff

Sequence, based on observed residues (ATOM records):

>d3b2wa1 d.144.1.7 (A:238-498) Lymphocyte kinase (lck) {Human (Homo sapiens) [TaxId: 9606]}
wevpretlklverlgagqfgevwmgyynghtkvavkslkqgsmspdaflaeanlmkqlqh
qrlvrlyavvtqepiyiiteymengslvdflktpsgikltinklldmaaqiaegmafiee
rnyihrdlraanilvsdtlsckiadfglarliedneytagakfpikwtapeainygtfti
ksdvwsfgillteivthgripypgmtnpeviqnlergyrmvrpdncpeelyqlmrlcwke
rpedrptfdylrsvledff

Timeline for d3b2wa1:

• d3b2wa1 is new in SCOP 1.75
  
• d3b2wa1 is called d3b2wa_ in SCOPe 2.01
  
• d3b2wa1 appears in the current release, SCOPe 2.08, called d3b2wa_