SCOPe 2.06: Domain d3b2ra2: 3b2r A:535-860

Lineage for d3b2ra2 (3b2r A:535-860)

1. Root: SCOPe 2.06

2. Class a: All alpha proteins [46456] (289 folds)

3. Fold a.211: HD-domain/PDEase-like [109603] (1 superfamily)
   multihelical; consists of two different alpha-helical bundles

4. Superfamily a.211.1: HD-domain/PDEase-like [109604] (6 families)

5. Family a.211.1.2: PDEase [48548] (7 proteins)
   Pfam PF00233; multihelical; can be divided into three subdomains

6. Protein cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx [101439] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [101440] (19 PDB entries)
   Uniprot O76074 534-860

8. Domain d3b2ra2: 3b2r A:535-860 [154768]
   Other proteins in same PDB: d3b2ra3
   automated match to d1rkpa_
   complexed with vdn

Details for d3b2ra2

PDB Entry: 3b2r, 2.07 Å

PDB Description: Crystal Structure of PDE5A1 catalytic domain in complex with Vardenafil

PDB Compounds: (A:) cGMP-specific 3',5'-cyclic phosphodiesterase

SCOPe Domain Sequences for d3b2ra2:

Sequence, based on SEQRES records:

>d3b2ra2 a.211.1.2 (A:535-860) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvnnsyiqrsehplaqlychsimehhhfdqclmilnspgnqilsglsieeykttlk
iikqailatdlalyikrrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpi
qqriaelvateffdqgdrerkelnieptdlmnrekknkipsmqvgfidaiclqlyealth
vsedcfplldgcrknrqkwqalaeqq

Sequence, based on observed residues (ATOM records):

>d3b2ra2 a.211.1.2 (A:535-860) cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1-Ibmx {Human (Homo sapiens) [TaxId: 9606]}
eetrelqslaaavvpsaqtlkitdfsfsdfelsdletalctirmftdlnlvqnfqmkhev
lcrwilsvkknyrknvayhnwrhafntaqcmfaalkagkiqnkltdleilalliaalshd
ldhrgvchsimehhhfdqclmilnspgnqilsglsieeykttlkiikqailatdlalyik
rrgeffelirknqfnledphqkelflamlmtacdlsaitkpwpiqqriaelvateffdqg
dkknkipsmqvgfidaiclqlyealthvsedcfplldgcrknrqkwqalaeqq

Timeline for d3b2ra2:

• d3b2ra2 first appeared in SCOP 1.75, called d3b2ra1
  
• d3b2ra2 was called d3b2ra_ in SCOPe 2.05
  
• d3b2ra2 appears in SCOPe 2.07
  
• d3b2ra2 appears in the current release, SCOPe 2.08