SCOPe 2.06: Domain d2zehb_: 2zeh B:

Lineage for d2zehb_ (2zeh B:)

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.56: Phosphorylase/hydrolase-like [53162] (8 superfamilies)
   core: 3 layers, a/b/a ; mixed sheet of 5 strands: order 21354; strand 4 is antiparallel to the rest; contains crossover loops

4. Superfamily c.56.5: Zn-dependent exopeptidases [53187] (10 families)
   core: mixed beta-sheet of 8 strands, order 12435867; strands 2, 6 & 7 are antiparallel to the rest

5. Family c.56.5.8: Glutaminyl-peptide cyclotransferase-like [142532] (1 protein)
   part of Pfam PF04389

6. Protein Glutaminyl-peptide cyclotransferase, QPCT [142533] (2 species)
   Glutaminyl cyclase

7. Species Human (Homo sapiens) [TaxId:9606] [142534] (22 PDB entries)
   Uniprot Q16769 33-361

8. Domain d2zehb_: 2zeh B: [154404]
   automated match to d2afma1
   complexed with so4, zn; mutant

Details for d2zehb_

PDB Entry: 2zeh, 1.8 Å

PDB Description: crystal structure of the human glutaminyl cyclase mutant e201q at 1.8 angstrom resolution

PDB Compounds: (B:) Glutaminyl-peptide cyclotransferase

SCOPe Domain Sequences for d2zehb_:

Sequence, based on SEQRES records:

>d2zehb_ c.56.5.8 (B:) Glutaminyl-peptide cyclotransferase, QPCT {Human (Homo sapiens) [TaxId: 9606]}
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslktvsdskpdlslqliffdgqeaflhwspqds
lygsrhlaakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlq
aiehelhelgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtm
ddneenldestidnlnkilqvfvleylhl

Sequence, based on observed residues (ATOM records):

>d2zehb_ c.56.5.8 (B:) Glutaminyl-peptide cyclotransferase, QPCT {Human (Homo sapiens) [TaxId: 9606]}
asawpeeknyhqpailnssalrqiaegtsisemwqndlqpllierypgspgsyaarqhim
qriqrlqadwvleidtflsqtpygyrsfsniistlnptakrhlvlachydskyfshwnnr
vfvgatdsavpcammlelaraldkkllslkpdlslqliffdgqeaflhwspqdslygsrh
laakmastphppgargtsqlhgmdllvlldligapnptfpnffpnsarwferlqaiehel
helgllkdhslegryfqnysyggviqddhipflrrgvpvlhlipspfpevwhtmddneen
ldestidnlnkilqvfvleylhl

Timeline for d2zehb_:

• d2zehb_ first appeared in SCOP 1.75, called d2zehb1
  
• d2zehb_ appears in SCOPe 2.05
  
• d2zehb_ appears in SCOPe 2.07
  
• d2zehb_ appears in the current release, SCOPe 2.08