SCOPe 2.08: Domain d2zb1a_: 2zb1 A:

Lineage for d2zb1a_ (2zb1 A:)

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
   consists of two alpha+beta domains, C-terminal domain is mostly alpha helical

4. Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families)
   shares functional and structural similarities with the ATP-grasp fold and PIPK

5. Family d.144.1.7: Protein kinases, catalytic subunit [88854] (66 proteins)
   members organized in the groups and subfamiles specified by the comments

6. Protein automated matches [190091] (20 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [188447] (850 PDB entries)

8. Domain d2zb1a_: 2zb1 A: [154298]
   automated match to d1a9ua_
   complexed with gk4, gol

Details for d2zb1a_

PDB Entry: 2zb1, 2.5 Å

PDB Description: crystal structure of p38 in complex with biphenyl amide inhibitor

PDB Compounds: (A:) Mitogen-activated protein kinase 14

SCOPe Domain Sequences for d2zb1a_:

Sequence, based on SEQRES records:

>d2zb1a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvgsgaygsvcaafdtktglrvavkklsrpfqsii
hakrtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqklt
ddhvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglarhtddemtgyv
atrwyrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpg
aellkkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqal
ahayfaqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Sequence, based on observed residues (ATOM records):

>d2zb1a_ d.144.1.7 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
erptfyrqelnktiwevperyqnlspvgaygsvcaafdtktglrvavkklsrpfqsiiha
krtyrelrllkhmkhenviglldvftparsleefndvylvthlmgadlnnivkcqkltdd
hvqfliyqilrglkyihsadiihrdlkpsnlavnedcelkildfglhtddemtgyvatrw
yrapeimlnwmhynqtvdiwsvgcimaelltgrtlfpgtdhidqlklilrlvgtpgaell
kkissesarnyiqsltqmpkmnfanvfiganplavdllekmlvldsdkritaaqalahay
faqyhdpddepvadpydqsfesrdllidewksltydevisfvppp

Timeline for d2zb1a_:

• d2zb1a_ first appeared in SCOP 1.75, called d2zb1a1
  
• d2zb1a_ appears in SCOPe 2.07