SCOP 1.75: Domain d2vg7b1: 2vg7 B:1005-1427

Lineage for d2vg7b1 (2vg7 B:1005-1427)

1. Root: SCOP 1.75

2. Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

3. Fold e.8: DNA/RNA polymerases [56671] (1 superfamily)
   divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

4. Superfamily e.8.1: DNA/RNA polymerases [56672] (6 families)
   "palm" domain has a ferredoxin-like fold, related to that of an adenylyl cyclase domain

5. Family e.8.1.2: Reverse transcriptase [56686] (2 proteins)

6. Protein HIV-1 reverse transcriptase [56689] (2 species)

7. Species Human immunodeficiency virus type 1 [TaxId:11676] [56690] (111 PDB entries)
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582
   Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584
   Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595
   Uniprot P04585 159-692 # chain A coverage; chain B is shorter: 162-582 ! Uniprot P03366 186-725 # chain A coverage; chain B coverage: 156-584 ! Uniprot P04585 158-698 # chain A coverage; chain B is shorter: 159-595

8. Domain d2vg7b1: 2vg7 B:1005-1427 [153033]
   automatically matched to d1c1bb_
   complexed with nni

Details for d2vg7b1

PDB Entry: 2vg7, 2.82 Å

PDB Description: crystal structures of hiv-1 reverse transcriptase complexes with thiocarbamate non-nucleoside inhibitors

PDB Compounds: (B:) p51 RT

SCOP Domain Sequences for d2vg7b1:

Sequence, based on SEQRES records:

>d2vg7b1 e.8.1.2 (B:1005-1427) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedf
rkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqym
ddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwtvqpi
vlpekdswtvndiqklvgklnwasqiypgikvrqlckllrgtkalteviplteeaelela
enreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtnd
vkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvk
lwy

Sequence, based on observed residues (ATOM records):

>d2vg7b1 e.8.1.2 (B:1005-1427) HIV-1 reverse transcriptase {Human immunodeficiency virus type 1 [TaxId: 11676]}
ietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpvfaik
kkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpldedfrkyt
aftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdiviyqymddly
vgsdleigqhrtkieelrqhllrwmgyelhpdkwtvqpivlpekdswtvndiqklvgkln
wasqiypgikvrqlckltkalteviplteeaelelaenreilkepvhgvyydpskdliae
iqkqgqgqwtyqiyqepfknlktgkyahtndvkqlteavqkittesiviwgktpkfklpi
qketwetwwteywqatwipewefvntpplvklwy

Timeline for d2vg7b1:

• d2vg7b1 is new in SCOP 1.75
  
• d2vg7b1 appears in SCOPe 2.01
  
• d2vg7b1 appears in the current release, SCOPe 2.08, called d2vg7b_