SCOPe 2.04: Domain d2va6a_: 2va6 A:

Lineage for d2va6a_ (2va6 A:)

1. Root: SCOPe 2.04

2. Class b: All beta proteins [48724] (176 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein automated matches [190156] (4 species)
   not a true protein

7. Species Human (Homo sapiens) [TaxId:9606] [187237] (38 PDB entries)

8. Domain d2va6a_: 2va6 A: [152822]
   automated match to d4hzta_
   complexed with h24, iod

Details for d2va6a_

PDB Entry: 2va6, 2.5 Å

PDB Description: x-ray crystal structure of beta secretase complexed with compound 24

PDB Compounds: (A:) beta secretase 1

SCOPe Domain Sequences for d2va6a_:

Sequence, based on SEQRES records:

>d2va6a_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcgyni

Sequence, based on observed residues (ATOM records):

>d2va6a_ b.50.1.2 (A:) automated matches {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgasvggsmiiggidhslytgslw
ytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaavksik
aasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfritilpqqylrpv
edvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachvhdefrtaa
vegpfvtldmedcgyni

Timeline for d2va6a_:

• d2va6a_ first appeared in SCOP 1.75, called d2va6a1
  
• d2va6a_ was called d2va6a1 in SCOPe 2.03
  
• d2va6a_ appears in SCOPe 2.05
  
• d2va6a_ appears in the current release, SCOPe 2.08