SCOPe 2.01: Domain d2v2wa2: 2v2w A:1-181

Lineage for d2v2wa2 (2v2w A:1-181)

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.19: MHC antigen-recognition domain [54451] (1 superfamily)
   dimeric

4. Superfamily d.19.1: MHC antigen-recognition domain [54452] (1 family)

5. Family d.19.1.1: MHC antigen-recognition domain [54453] (13 proteins)

6. Protein Class I MHC, alpha-1 and alpha-2 domains [54468] (27 species)

7. Species Human (Homo sapiens), HLA-A2.1 [TaxId:9606] [54470] (76 PDB entries)
   Uniprot P01892 25-298

8. Domain d2v2wa2: 2v2w A:1-181 [152428]
   Other proteins in same PDB: d2v2wa1, d2v2wb_, d2v2wd1, d2v2we_
   automatically matched to d1akja2

Details for d2v2wa2

PDB Entry: 2v2w, 1.6 Å

PDB Description: t cell cross-reactivity and conformational changes during tcr engagement

PDB Compounds: (A:) HLA class I histocompatibility antigen, A-2 alpha chain

SCOPe Domain Sequences for d2v2wa2:

Sequence; same for both SEQRES and ATOM records:

>d2v2wa2 d.19.1.1 (A:1-181) Class I MHC, alpha-1 and alpha-2 domains {Human (Homo sapiens), HLA-A2.1 [TaxId: 9606]}
gshsmryfftsvsrpgrgeprfiavgyvddtqfvrfdsdaasqrmeprapwieqegpeyw
dgetrkvkahsqthrvdlgtlrgyynqseagshtvqrmygcdvgsdwrflrgyhqyaydg
kdyialkedlrswtaadmaaqttkhkweaahvaeqlraylegtcvewlrrylengketlq
r

Timeline for d2v2wa2:

• d2v2wa2 first appeared in SCOP 1.75
  
• d2v2wa2 appears in SCOPe 2.02
  
• d2v2wa2 appears in the current release, SCOPe 2.08