SCOPe 2.03: Domain d2uxxa2: 2uxx A:274-654,A:764-835

Lineage for d2uxxa2 (2uxx A:274-654,A:764-835)

1. Root: SCOPe 2.03

2. Class c: Alpha and beta proteins (a/b) [51349] (147 folds)

3. Fold c.3: FAD/NAD(P)-binding domain [51904] (1 superfamily)
   core: 3 layers, b/b/a; central parallel beta-sheet of 5 strands, order 32145; top antiparallel beta-sheet of 3 strands, meander

4. Superfamily c.3.1: FAD/NAD(P)-binding domain [51905] (8 families)

5. Family c.3.1.2: FAD-linked reductases, N-terminal domain [51913] (18 proteins)
   C-terminal domain is alpha+beta is common for the family

6. Protein Lysine-specific histone demethylase 1, LSD1 [159432] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [159433] (8 PDB entries)
   Uniprot O60341 274-654,764-836

8. Domain d2uxxa2: 2uxx A:274-654,A:764-835 [152311]
   Other proteins in same PDB: d2uxxa1, d2uxxa3
   automated match to d2iw5a2
   complexed with cl, faj, gol

Details for d2uxxa2

PDB Entry: 2uxx, 2.74 Å

PDB Description: human lsd1 histone demethylase-corest in complex with an fad- tranylcypromine adduct

PDB Compounds: (A:) Lysine-specific histone demethylase 1

SCOPe Domain Sequences for d2uxxa2:

Sequence; same for both SEQRES and ATOM records:

>d2uxxa2 c.3.1.2 (A:274-654,A:764-835) Lysine-specific histone demethylase 1, LSD1 {Human (Homo sapiens) [TaxId: 9606]}
ptkktgkviiigsgvsglaaarqlqsfgmdvtlleardrvggrvatfrkgnyvadlgamv
vtglggnpmavvskqvnmelakikqkcplyeangqavpkekdemveqefnrlleatsyls
hqldfnvlnnkpvslgqalevviqlqekhvkdeqiehwkkivktqeelkellnkmvnlke
kikelhqqykeasevkpprditaeflvkskhrdltalckeydelaetqgkleeklqelea
nppsdvylssrdrqildwhfanlefanatplstlslkhwdqdddfeftgshltvrngysc
vpvalaegldiklntavrqvrytasgceviavntrstsqtfiykcdavlctlplgvlkqq
ppavqfvpplpewktsavqrmXvaagssgndydlmaqpitpgpsipgapqpiprlffage
htirnypatvhgallsglreagriadqflgamyt

Timeline for d2uxxa2:

• d2uxxa2 first appeared in SCOP 1.75
  
• d2uxxa2 appears in SCOPe 2.02
  
• d2uxxa2 appears in SCOPe 2.04
  
• d2uxxa2 appears in the current release, SCOPe 2.08