Lineage for d2uv2a1 (2uv2 A:21-308)

  1. Root: SCOP 1.75
  2. 849709Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 874255Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 874256Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (7 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK
  5. 874317Family d.144.1.7: Protein kinases, catalytic subunit [88854] (63 proteins)
    members organized in the groups and subfamiles specified by the comments
  6. 875163Protein STE20-like serine/threonine-protein kinase, SLK [160812] (1 species)
  7. 875164Species Human (Homo sapiens) [TaxId:9606] [160813] (3 PDB entries)
    Uniprot Q9H2G2 21-308
  8. 875166Domain d2uv2a1: 2uv2 A:21-308 [152203]
    complexed with edo, gvd, scn; mutant

Details for d2uv2a1

PDB Entry: 2uv2 (more details), 2.3 Å

PDB Description: crystal structure of human ste20-like kinase bound to 4-(4-(5- cyclopropyl-1h-pyrazol-3-ylamino)-quinazolin-2-ylamino)-phenyl)- acetonitrile
PDB Compounds: (A:) ste20-like serine-threonine kinase

SCOP Domain Sequences for d2uv2a1:

Sequence, based on SEQRES records: (download)

>d2uv2a1 d.144.1.7 (A:21-308) STE20-like serine/threonine-protein kinase, SLK {Human (Homo sapiens) [TaxId: 9606]}
yehvtrdlnpedfweiigelgdgafgkvykaqnketsvlaaakvidtkseeeledymvei
dilascdhpnivklldafyyennlwiliefcaggavdavmlelerpltesqiqvvckqtl
dalnylhdnkiihrdlkagnilftldgdikladfgvsakntrtiqrrdsfigtpywmape
vvmcetskdrpydykadvwslgitliemaeiepphhelnpmrvllkiaksepptlaqpsr
wssnfkdflkkcleknvdarwttsqllqhpfvtvdsnkpireliaeak

Sequence, based on observed residues (ATOM records): (download)

>d2uv2a1 d.144.1.7 (A:21-308) STE20-like serine/threonine-protein kinase, SLK {Human (Homo sapiens) [TaxId: 9606]}
yehvtrdlnpedfweiigelgdfgkvykaqnketsvlaaakvidtkseeeledymveidi
lascdhpnivklldafyyennlwiliefcaggavdavmlelerpltesqiqvvckqtlda
lnylhdnkiihrdlkagnilftldgdikladfgvsakntrtiqrrdsfigtpywmapevv
mcetskdrpydykadvwslgitliemaeiepphhelnpmrvllkiaksepptlaqpsrws
snfkdflkkcleknvdarwttsqllqhpfvtvdsnkpireliaeak

SCOP Domain Coordinates for d2uv2a1:

Click to download the PDB-style file with coordinates for d2uv2a1.
(The format of our PDB-style files is described here.)

Timeline for d2uv2a1: