SCOPe 2.07: Domain d2rh4a_: 2rh4 A:

Lineage for d2rh4a_ (2rh4 A:)

1. Root: SCOPe 2.07

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
   core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
   The nucleotide-binding modes of this and the next two folds/superfamilies are similar

4. Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families)

5. Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 proteins)
   also known as short-chain dehydrogenases and SDR family
   parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7

6. Protein beta-keto acyl carrier protein reductase [51788] (8 species)

7. Species Streptomyces coelicolor [TaxId:1902] [117408] (8 PDB entries)
   Uniprot P16544 #SP

8. Domain d2rh4a_: 2rh4 A: [152028]
   Other proteins in same PDB: d2rh4b3
   automated match to d1w4zb_
   complexed with emo, ndp

Details for d2rh4a_

PDB Entry: 2rh4, 2.3 Å

PDB Description: Actinorhodin ketoreductase, actKR, with NADPH and Inhibitor Emodin

PDB Compounds: (A:) Actinorhodin Polyketide Ketoreductase

SCOPe Domain Sequences for d2rh4a_:

Sequence; same for both SEQRES and ATOM records:

>d2rh4a_ c.2.1.2 (A:) beta-keto acyl carrier protein reductase {Streptomyces coelicolor [TaxId: 1902]}
dsevalvtgatsgigleiarrlgkeglrvfvcargeeglrttlkelreagveadgrtcdv
rsvpeiealvaavverygpvdvlvnnagrpgggataeladelwldvvetnltgvfrvtkq
vlkaggmlergtgrivniastggkqgvvhaapysaskhgvvgftkalglelartgitvna
vcpgfvetpmaasvrehysdiwevsteeafdritarvpigryvqpsevaemvayligpga
aavtaqalnvcgglgny

Timeline for d2rh4a_:

• d2rh4a_ first appeared in SCOP 1.75, called d2rh4a1
  
• d2rh4a_ appears in SCOPe 2.06
  
• d2rh4a_ appears in the current release, SCOPe 2.08