SCOPe 2.07: Domain d2rcje2: 2rcj E:120-218

Lineage for d2rcje2 (2rcj E:120-218)

1. Root: SCOPe 2.07

2. Class b: All beta proteins [48724] (178 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (184 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d2rcje2: 2rcj E:120-218 [151895]
   Other proteins in same PDB: d2rcja1, d2rcjb1, d2rcje1, d2rcjf1, d2rcji1, d2rcjj1, d2rcjm1, d2rcjn1, d2rcjq1, d2rcjr1
   automatically matched to d2ig2h2

Details for d2rcje2

PDB Entry: 2rcj

PDB Description: solution structure of human immunoglobulin m

PDB Compounds: (E:) Immunoglobulin M heavy chain

SCOPe Domain Sequences for d2rcje2:

Sequence; same for both SEQRES and ATOM records:

>d2rcje2 b.1.1.2 (E:120-218) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
stkgpsvfplapsskstsggtaalgclvkdyfpqpvtvswnsgaltsgvhtfpavlqssg
lyslssvvtvpssslgtqtyicnvnhkpsntkvdkrvep

Timeline for d2rcje2:

• d2rcje2 first appeared in SCOP 1.75
  
• d2rcje2 appears in SCOPe 2.06
  
• d2rcje2 appears in the current release, SCOPe 2.08