Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily) core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456 The nucleotide-binding modes of this and the next two folds/superfamilies are similar |
Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (12 families) |
Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (70 proteins) also known as short-chain dehydrogenases and SDR family parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7 |
Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species) |
Species Human (Homo sapiens) [TaxId:9606] [117424] (11 PDB entries) Uniprot P28845 |
Domain d2rbeb1: 2rbe B:27-281 [151847] automatically matched to d1xu9b_ complexed with ndp, zmg; mutant |
PDB Entry: 2rbe (more details), 1.9 Å
SCOP Domain Sequences for d2rbeb1:
Sequence; same for both SEQRES and ATOM records: (download)
>d2rbeb1 c.2.1.2 (B:27-281) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]} frpemlqgkkvivtgaskgigremayhlakmgahvvvtarsketlqkvvshclelgaasa hyiagtmedmtfaeqfvaqagklmggldmlilnhitntslnlfhddihhvrksmevnfls yvvltvaalpmlkqsngsivvvsslagkvaypmvaaysaskfaldgffssirkeysvsrv nvsitlcvlglidtetamkavsgivhmqaapkeecaleiikggalrqeevyydsslwttl lirnpsrkileflys
Timeline for d2rbeb1: