Lineage for d2rbeb_ (2rbe B:)

  1. Root: SCOPe 2.06
  2. 2078559Class c: Alpha and beta proteins (a/b) [51349] (148 folds)
  3. 2090218Fold c.2: NAD(P)-binding Rossmann-fold domains [51734] (1 superfamily)
    core: 3 layers, a/b/a; parallel beta-sheet of 6 strands, order 321456
    The nucleotide-binding modes of this and the next two folds/superfamilies are similar
  4. 2090219Superfamily c.2.1: NAD(P)-binding Rossmann-fold domains [51735] (13 families) (S)
  5. 2090553Family c.2.1.2: Tyrosine-dependent oxidoreductases [51751] (71 protein domains)
    also known as short-chain dehydrogenases and SDR family
    parallel beta-sheet is extended by 7th strand, order 3214567; left-handed crossover connection between strands 6 and 7
  6. 2090580Protein 11-beta-hydroxysteroid dehydrogenase 1 [117423] (3 species)
  7. 2090596Species Human (Homo sapiens) [TaxId:9606] [117424] (29 PDB entries)
    Uniprot P28845
  8. 2090610Domain d2rbeb_: 2rbe B: [151847]
    automated match to d1xu9a_
    complexed with ndp, zmg

Details for d2rbeb_

PDB Entry: 2rbe (more details), 1.9 Å

PDB Description: The discovery of 2-anilinothiazolones as 11beta-HSD1 inhibitors
PDB Compounds: (B:) Corticosteroid 11-beta-dehydrogenase isozyme 1

SCOPe Domain Sequences for d2rbeb_:

Sequence; same for both SEQRES and ATOM records: (download)

>d2rbeb_ c.2.1.2 (B:) 11-beta-hydroxysteroid dehydrogenase 1 {Human (Homo sapiens) [TaxId: 9606]}

SCOPe Domain Coordinates for d2rbeb_:

Click to download the PDB-style file with coordinates for d2rbeb_.
(The format of our PDB-style files is described here.)

Timeline for d2rbeb_: