SCOPe 2.08: Domain d2r0kh2: 2r0k H:114-212

Lineage for d2r0kh2 (2r0k H:114-212)

1. Root: SCOPe 2.08

2. Class b: All beta proteins [48724] (180 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma [88574] (7 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88575] (173 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   Uniprot Q6N089 20-243 # 95% sequence identity; natural chimera: antibody heavy chain (Fab HYB3) ! SQ NA # humanized antibody ! Uniprot P01857 # IGHG1_HUMAN Ig gamma-1 chain C region ! SQ NA # engineered antibody

8. Domain d2r0kh2: 2r0k H:114-212 [151501]
   Other proteins in same PDB: d2r0kh1
   automatically matched to d1uj3b2

Details for d2r0kh2

PDB Entry: 2r0k, 3.51 Å

PDB Description: protease domain of hgfa with inhibitor fab58

PDB Compounds: (H:) antibody heavy chain of Fab58, Fab portion only

SCOPe Domain Sequences for d2r0kh2:

Sequence, based on SEQRES records:

>d2r0kh2 b.1.1.2 (H:114-212) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapsskstsggtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqss
glyslssvvtvpssslgtqtyicnvnhkpsntkvdkkve

Sequence, based on observed residues (ATOM records):

>d2r0kh2 b.1.1.2 (H:114-212) Immunoglobulin heavy chain gamma constant domain 1, CH1-gamma {Human (Homo sapiens) [TaxId: 9606]}
astkgpsvfplapgtaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglyslss
vvtvpssslgtqtyicnvnhkpsntkvdkkve

Timeline for d2r0kh2:

• d2r0kh2 first appeared in SCOP 1.75
  
• d2r0kh2 appears in SCOPe 2.07