SCOPe 2.06: Domain d2qu2a_: 2qu2 A:

Lineage for d2qu2a_ (2qu2 A:)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.50: Acid proteases [50629] (1 superfamily)
   barrel, closed; n=6, S=10, complex topology

4. Superfamily b.50.1: Acid proteases [50630] (4 families)

5. Family b.50.1.2: Pepsin-like [50646] (11 proteins)
   duplication: consists of two similar barrel domains
   N-terminal: barrel, partly opened; n*=6, S*=10

6. Protein beta-secretase (memapsin) [50671] (1 species)

7. Species Human (Homo sapiens) [TaxId:9606] [50672] (281 PDB entries)
   Uniprot P56817 58-446 ! Uniprot P56817 60-447

8. Domain d2qu2a_: 2qu2 A: [151363]
   automated match to d1fkna_
   complexed with 251

Details for d2qu2a_

PDB Entry: 2qu2, 2.6 Å

PDB Description: BACE1 with Compound 1

PDB Compounds: (A:) Beta-secretase 1

SCOPe Domain Sequences for d2qu2a_:

Sequence, based on SEQRES records:

>d2qu2a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
sfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqls
styrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnweg
ilglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiig
gidhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlp
kkvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfr
itilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavs
achvhdefrtaavegpfvtldmedcg

Sequence, based on observed residues (ATOM records):

>d2qu2a_ b.50.1.2 (A:) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
sfvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqls
styrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnweg
ilglayaeiarpddslepffdslvkqthvpnlfslqlcgasevlasvggsmiiggidhsl
ytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfea
avksikaasstekfpdgfwlgeqlvcwagttpwnifpvislylmgevtnqsfritilpqq
ylrpvdcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachdefrtaavegpf
vdcg

Timeline for d2qu2a_:

• d2qu2a_ first appeared in SCOP 1.75, called d2qu2a1
  
• d2qu2a_ appears in SCOPe 2.05
  
• d2qu2a_ appears in SCOPe 2.07
  
• d2qu2a_ appears in the current release, SCOPe 2.08