Lineage for d2qu2a1 (2qu2 A:61-445)

  1. Root: SCOP 1.75
  2. 781541Class b: All beta proteins [48724] (174 folds)
  3. 803906Fold b.50: Acid proteases [50629] (1 superfamily)
    barrel, closed; n=6, S=10, complex topology
  4. 803907Superfamily b.50.1: Acid proteases [50630] (3 families) (S)
  5. 804499Family b.50.1.2: Pepsin-like [50646] (10 protein domains)
    duplication: consists of two similar barrel domains
    N-terminal: barrel, partly opened; n*=6, S*=10
  6. 804554Protein beta-secretase (memapsin) [50671] (1 species)
  7. 804555Species Human (Homo sapiens) [TaxId:9606] [50672] (51 PDB entries)
    Uniprot P56817 58-446
    Uniprot P56817 60-447
    Uniprot P56817 58-446 ! Uniprot P56817 60-447
  8. 804644Domain d2qu2a1: 2qu2 A:61-445 [151363]
    automatically matched to d1fkna_
    complexed with 251

Details for d2qu2a1

PDB Entry: 2qu2 (more details), 2.6 Å

PDB Description: BACE1 with Compound 1
PDB Compounds: (A:) Beta-secretase 1

SCOP Domain Sequences for d2qu2a1:

Sequence, based on SEQRES records: (download)

>d2qu2a1 b.50.1.2 (A:61-445) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgagfplnqsevlasvggsmiigg
idhslytgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpk
kvfeaavksikaasstekfpdgfwlgeqlvcwqagttpwnifpvislylmgevtnqsfri
tilpqqylrpvedvatsqddcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsa
chvhdefrtaavegpfvtldmedcg

Sequence, based on observed residues (ATOM records): (download)

>d2qu2a1 b.50.1.2 (A:61-445) beta-secretase (memapsin) {Human (Homo sapiens) [TaxId: 9606]}
fvemvdnlrgksgqgyyvemtvgsppqtlnilvdtgssnfavgaaphpflhryyqrqlss
tyrdlrkgvyvpytqgkwegelgtdlvsiphgpnvtvraniaaitesdkffingsnwegi
lglayaeiarpddslepffdslvkqthvpnlfslqlcgasevlasvggsmiiggidhsly
tgslwytpirrewyyeviivrveingqdlkmdckeynydksivdsgttnlrlpkkvfeaa
vksikaasstekfpdgfwlgeqlvcwagttpwnifpvislylmgevtnqsfritilpqqy
lrpvdcykfaisqsstgtvmgavimegfyvvfdrarkrigfavsachdefrtaavegpfv
dcg

SCOP Domain Coordinates for d2qu2a1:

Click to download the PDB-style file with coordinates for d2qu2a1.
(The format of our PDB-style files is described here.)

Timeline for d2qu2a1: