SCOPe 2.06: Domain d2qscl2: 2qsc L:108-214

Lineage for d2qscl2 (2qsc L:108-214)

1. Root: SCOPe 2.06

2. Class b: All beta proteins [48724] (177 folds)

3. Fold b.1: Immunoglobulin-like beta-sandwich [48725] (33 superfamilies)
   sandwich; 7 strands in 2 sheets; greek-key
   some members of the fold have additional strands

4. Superfamily b.1.1: Immunoglobulin [48726] (5 families)

5. Family b.1.1.2: C1 set domains (antibody constant domain-like) [48942] (24 proteins)

6. Protein Immunoglobulin light chain kappa constant domain, CL-kappa [88566] (4 species)

7. Species Human (Homo sapiens) [TaxId:9606] [88569] (144 PDB entries)
   including humanized antibodies (chimeric proteins with human constant domains)
   SQ NA # humanized antibody ! Uniprot P01834 # KAC_HUMAN Ig kappa chain C region ! SQ P01834 # KAC_HUMAN Ig kappa chain C region. ! SQ NA # engineered antibody

8. Domain d2qscl2: 2qsc L:108-214 [151317]
   Other proteins in same PDB: d2qscl1
   automatically matched to d1rhha2
   complexed with cl, zn

Details for d2qscl2

PDB Entry: 2qsc, 2.8 Å

PDB Description: crystal structure analysis of anti-hiv-1 v3-fab f425-b4e8 in complex with a v3-peptide

PDB Compounds: (L:) Fab F425-B4e8, Light chain

SCOPe Domain Sequences for d2qscl2:

Sequence; same for both SEQRES and ATOM records:

>d2qscl2 b.1.1.2 (L:108-214) Immunoglobulin light chain kappa constant domain, CL-kappa {Human (Homo sapiens) [TaxId: 9606]}
rtvaapsvfifppsdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqd
skdstyslsstltlskadyekhkvyacevthqglsspvtksfnrgec

Timeline for d2qscl2:

• d2qscl2 first appeared in SCOP 1.75
  
• d2qscl2 appears in SCOPe 2.05
  
• d2qscl2 appears in SCOPe 2.07
  
• d2qscl2 appears in the current release, SCOPe 2.08