SCOP 1.75: Domain d2qpja1: 2qpj A:54-749

Lineage for d2qpja1 (2qpj A:54-749)

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (17 families)

5. Family d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (1 protein)

6. Protein Neutral endopeptidase (neprilysin) [55503] (1 species)
   contains thermolysin-like catalytic domain (residues 419-749)
   the N-terminal half of the structure is multihelical

7. Species Human (Homo sapiens) [TaxId:9606] [55504] (6 PDB entries)
   Uniprot P08473 54-749

8. Domain d2qpja1: 2qpj A:54-749 [151205]
   automatically matched to d1dmta_
   complexed with i20, nag, zn

Details for d2qpja1

PDB Entry: 2qpj, 2.05 Å

PDB Description: human nep complexed with a bifunctional nep/dpp iv inhibitor

PDB Compounds: (A:) Neprilysin

SCOP Domain Sequences for d2qpja1:

Sequence; same for both SEQRES and ATOM records:

>d2qpja1 d.92.1.4 (A:54-749) Neutral endopeptidase (neprilysin) {Human (Homo sapiens) [TaxId: 9606]}
gickssdciksaarliqnmdattepctdffkyacggwlkrnvipetssrygnfdilrdel
evvlkdvlqepktedivavqkakalyrscinesaidsrggepllkllpdiygwpvatenw
eqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidqprlglpsrdyyec
tgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelekeianatakpedrn
dpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitneedvvvyapeyltk
lkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalygttsetatwrrcany
vngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkraeekal
aikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdkde
wisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfddng
rnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlngintlgeniadngg
lgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpeyavnsiktdvhsp
gnfriigtlqnsaefseafhcrknsymnpekkcrvw

Timeline for d2qpja1:

• d2qpja1 is new in SCOP 1.75
  
• d2qpja1 is called d2qpja_ in SCOPe 2.01
  
• d2qpja1 appears in the current release, SCOPe 2.08, called d2qpja_